HCSGD entry for PDGFA

1. General information

Official gene symbolPDGFA
Entrez ID5154
Gene full nameplatelet-derived growth factor alpha polypeptide
Other gene symbolsPDGF-A PDGF1
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

color bar
This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000139Golgi membraneTAScellular_component
GO:0001525AngiogenesisISSbiological_process
GO:0001666Response to hypoxiaIEAbiological_process
GO:0001775Cell activationTASbiological_process
GO:0001942Hair follicle developmentISSbiological_process
GO:0002053Positive regulation of mesenchymal cell proliferationISSbiological_process
GO:0002576Platelet degranulationTASbiological_process
GO:0005161Platelet-derived growth factor receptor bindingIDA IPImolecular_function
GO:0005518Collagen bindingIDAmolecular_function
GO:0005576Extracellular regionTAScellular_component
GO:0005615Extracellular spaceIDAcellular_component
GO:0005788Endoplasmic reticulum lumenTAScellular_component
GO:0005902MicrovillusISScellular_component
GO:0007173Epidermal growth factor receptor signaling pathwayTASbiological_process
GO:0007179Transforming growth factor beta receptor signaling pathwayIEAbiological_process
GO:0007267Cell-cell signalingTASbiological_process
GO:0007596Blood coagulationTASbiological_process
GO:0008083Growth factor activityIDA IEAmolecular_function
GO:0008284Positive regulation of cell proliferationIDAbiological_process
GO:0008543Fibroblast growth factor receptor signaling pathwayTASbiological_process
GO:0009611Response to woundingIDAbiological_process
GO:0009790Embryo developmentTASbiological_process
GO:0009887Organ morphogenesisISSbiological_process
GO:0009986Cell surfaceIDAcellular_component
GO:0010035Response to inorganic substanceIEAbiological_process
GO:0010512Negative regulation of phosphatidylinositol biosynthetic processIDAbiological_process
GO:0010544Negative regulation of platelet activationIDAbiological_process
GO:0014068Positive regulation of phosphatidylinositol 3-kinase signalingIDAbiological_process
GO:0014910Regulation of smooth muscle cell migrationIDAbiological_process
GO:0016020MembraneIEAcellular_component
GO:0030031Cell projection assemblyISSbiological_process
GO:0030036Actin cytoskeleton organizationISSbiological_process
GO:0030168Platelet activationTASbiological_process
GO:0030198Extracellular matrix organizationTASbiological_process
GO:0030335Positive regulation of cell migrationIDAbiological_process
GO:0031093Platelet alpha granule lumenTAScellular_component
GO:0031954Positive regulation of protein autophosphorylationIDAbiological_process
GO:0032355Response to estradiolIEAbiological_process
GO:0032526Response to retinoic acidIEAbiological_process
GO:0032956Regulation of actin cytoskeleton organizationTASbiological_process
GO:0035793Positive regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathwayIDAbiological_process
GO:0038095Fc-epsilon receptor signaling pathwayTASbiological_process
GO:0042060Wound healingTASbiological_process
GO:0042493Response to drugIEAbiological_process
GO:0042803Protein homodimerization activityIDAmolecular_function
GO:0043406Positive regulation of MAP kinase activityIDAbiological_process
GO:0043410Positive regulation of MAPK cascadeIMPbiological_process
GO:0043588Skin developmentISSbiological_process
GO:0045087Innate immune responseTASbiological_process
GO:0045740Positive regulation of DNA replicationIDAbiological_process
GO:0046982Protein heterodimerization activityIPImolecular_function
GO:0048008Platelet-derived growth factor receptor signaling pathwayIDAbiological_process
GO:0048011Neurotrophin TRK receptor signaling pathwayTASbiological_process
GO:0048015Phosphatidylinositol-mediated signalingTASbiological_process
GO:0048146Positive regulation of fibroblast proliferationIDAbiological_process
GO:0048286Lung alveolus developmentISSbiological_process
GO:0048407Platelet-derived growth factor bindingIPImolecular_function
GO:0048839Inner ear developmentIEAbiological_process
GO:0050730Regulation of peptidyl-tyrosine phosphorylationISSbiological_process
GO:0050919Negative chemotaxisIDAbiological_process
GO:0051781Positive regulation of cell divisionIEAbiological_process
GO:0051897Positive regulation of protein kinase B signalingIDAbiological_process
GO:0060683Regulation of branching involved in salivary gland morphogenesis by epithelial-mesenchymal signalingISSbiological_process
GO:0070374Positive regulation of ERK1 and ERK2 cascadeIDAbiological_process
GO:0072124Regulation of glomerular mesangial cell proliferationIDAbiological_process
GO:2000278Regulation of DNA biosynthetic processIDAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.98754651420.00687121310.99999024730.1653088342

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.1230363931
GSE13712_SHEARUp0.0813244004
GSE13712_STATICDown-0.1937844427
GSE19018Down-0.3637356383
GSE19899_A1Down-0.3714410415
GSE19899_A2Down-0.5170903931
PubMed_21979375_A1Up0.0196905884
PubMed_21979375_A2Down-1.1755587137
GSE35957Down-0.7269310569
GSE36640Down-1.0588780502
GSE54402Down-0.0835210168
GSE9593Down-0.2953039457
GSE43922Down-0.2313637528
GSE24585Down-0.3761696608
GSE37065Down-0.3548339364
GSE28863_A1Down-0.2544924557
GSE28863_A2Down-0.0519103136
GSE28863_A3Down-0.0959566810
GSE28863_A4Down-0.3604953451
GSE48662Up0.6171235790

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-let-7d-5pMIMAT0000065MIRT005549ELISA//Immunoblot//Microarray//qRT-PCRFunctional MTI (Weak)21266476
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    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 4 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

19085240Proliferation, cell viability, mineralization assays, and mRNA levels were assessed for type I and III collagen, platelet-derived growth factor (PDGF)-1, basic fibroblast growth factor (bFGF), metalloproteinase (MMP)-2 and-8, and tissue inhibitor of metalloproteinases (TIMP)-1 and-2
19085240Gene expression analysis further showed that mRNA levels for bFGF, PDGF-1, and TIMP-2 were not affected by aging (p > 0
19054066Platination of telomeric sequences and nuclease hypersensitive elements of human c-myc and PDGF-A promoters and their ability to form G-quadruplexes
19054066The telomeric regions of DNA and nuclease hypersensitive elements of human c-myc and PDGF-A promoters represent a very appealing target for cisplatin and may interfere with normal DNA function
8106562We have previously found that stimulation of normal neonatal fibroblasts with PDGF or EGF leads to a transient induction of PDGF A-chain mRNA and the synthesis of PDGF-AA proteins
8106562We have now studied the PDGF-BB mediated PDGF A-chain induction in a set of fibroblasts from young and old donors to clarify if the levels of induction are correlated to the donor age and the replicative capacity of the cells
8106562The PDGF A-chain induction was found to be reduced in cells from old donors compared with cells from embryonic and neonatal donors
8106562The PDGF A-chain mRNA induction was also decreased or absent in late passage human fibroblasts (senescent cells) when compared with early passage cells
8106562These data suggest that the PDGF A-chain mRNA induction is regulated by an age related mechanism in human fibroblasts
2166059Although normal fibroblasts only express platelet-derived growth factor (PDGF) A-chain mRNA for a brief period following mitogenic stimulation, one strain of Hutchinson-Gilford (progeria) syndrome fibroblasts, AG3513, constitutively expresses PDGF A-chain mRNA and PDGF-AA homodimers
2166059The PDGF A-chain gene does not appear to be amplified or rearranged in these fibroblasts
2166059The senescent phenotype of AG3513 fibroblasts is probably unrelated to their constitutive PDGF A-chain gene expression; further studies are necessary in order to directly address this issue
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