HCSGD entry for PDE1B

1. General information

Official gene symbolPDE1B
Entrez ID5153
Gene full namephosphodiesterase 1B, calmodulin-dependent
Other gene symbolsPDE1B1 PDES1B
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0001505Regulation of neurotransmitter levelsIEAbiological_process
GO:0001975Response to amphetamineIEAbiological_process
GO:00041153',5'-cyclic-AMP phosphodiesterase activityIEAmolecular_function
GO:0004117Calmodulin-dependent cyclic-nucleotide phosphodiesterase activityTASmolecular_function
GO:0005516Calmodulin bindingIEAmolecular_function
GO:0005634NucleusIDAcellular_component
GO:0005730NucleolusIDAcellular_component
GO:0005737CytoplasmIDAcellular_component
GO:0005829CytosolTAScellular_component
GO:0006198CAMP catabolic processIDA IEAbiological_process
GO:0006915Apoptotic processTASbiological_process
GO:0007165Signal transductionIEA TASbiological_process
GO:0007173Epidermal growth factor receptor signaling pathwayTASbiological_process
GO:0007202Activation of phospholipase C activityTASbiological_process
GO:0007596Blood coagulationTASbiological_process
GO:0007626Locomotory behaviorIEAbiological_process
GO:0008542Visual learningIEAbiological_process
GO:0008543Fibroblast growth factor receptor signaling pathwayTASbiological_process
GO:0030224Monocyte differentiationIEPbiological_process
GO:0036006Cellular response to macrophage colony-stimulating factor stimulusIDAbiological_process
GO:0042053Regulation of dopamine metabolic processIEAbiological_process
GO:0042428Serotonin metabolic processIEAbiological_process
GO:0043025Neuronal cell bodyIEAcellular_component
GO:0045087Innate immune responseTASbiological_process
GO:0046069CGMP catabolic processIDA IEAbiological_process
GO:0046872Metal ion bindingIEAmolecular_function
GO:0048011Neurotrophin TRK receptor signaling pathwayTASbiological_process
GO:0048101Calcium- and calmodulin-regulated 3',5'-cyclic-GMP phosphodiesterase activityIEAmolecular_function
GO:0097011Cellular response to granulocyte macrophage colony-stimulating factor stimulusIDAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.53129042590.52337954860.99999024731.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.0860338339
GSE13712_SHEARUp0.0246640915
GSE13712_STATICDown-0.0715067058
GSE19018Up0.4866589930
GSE19899_A1Up0.0317688798
GSE19899_A2Down-0.0618520517
PubMed_21979375_A1Up0.0081643499
PubMed_21979375_A2Down-0.1570897636
GSE35957Up0.0276334946
GSE36640Up0.0252267599
GSE54402Up0.0912147243
GSE9593Up0.2243218408
GSE43922Up0.0203023649
GSE24585Down-0.6166166360
GSE37065Up0.0488883684
GSE28863_A1Down-0.1834275896
GSE28863_A2Up0.0249985418
GSE28863_A3Up0.3000754277
GSE28863_A4Up0.0682596969
GSE48662Up0.0223575153

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

NicardipineDB00622 APRD00088
BepridilDB01244 APRD00727
S,S-(2-Hydroxyethyl)ThiocysteineDB04530 EXPT00954

  • MicroRNAs

    • mirTarBase
No target information from mirTarBase
    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.