HCSGD entry for LARS
1. General information
| Official gene symbol | LARS |
|---|---|
| Entrez ID | 51520 |
| Gene full name | leucyl-tRNA synthetase |
| Other gene symbols | HSPC192 LARS1 LEURS LEUS LRS PIG44 RNTLS hr025Cl |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0002161 | Aminoacyl-tRNA editing activity | IEA | molecular_function |
| GO:0004823 | Leucine-tRNA ligase activity | IEA TAS | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005524 | ATP binding | IEA | molecular_function |
| GO:0005737 | Cytoplasm | IEA | cellular_component |
| GO:0005829 | Cytosol | TAS | cellular_component |
| GO:0006418 | TRNA aminoacylation for protein translation | TAS | biological_process |
| GO:0006429 | Leucyl-tRNA aminoacylation | IEA | biological_process |
| GO:0010467 | Gene expression | TAS | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.6523237567 | 0.1639895331 | 0.9999902473 | 0.7828016866 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.2708500106 |
| GSE13712_SHEAR | Up | 0.1696859996 |
| GSE13712_STATIC | Down | -0.0079294407 |
| GSE19018 | Up | 0.0462909994 |
| GSE19899_A1 | Down | -0.0952847555 |
| GSE19899_A2 | Down | -0.1303892757 |
| PubMed_21979375_A1 | Down | -0.0272249321 |
| PubMed_21979375_A2 | Down | -0.2958193464 |
| GSE35957 | Up | 0.1128662846 |
| GSE36640 | Down | -0.3599294137 |
| GSE54402 | Down | -0.0393660026 |
| GSE9593 | Up | 0.0662105800 |
| GSE43922 | Down | -0.0379841555 |
| GSE24585 | Down | -0.3333179191 |
| GSE37065 | Down | -0.3960353644 |
| GSE28863_A1 | Up | 0.4317051104 |
| GSE28863_A2 | Up | 0.3421536738 |
| GSE28863_A3 | Down | -0.2911438675 |
| GSE28863_A4 | Down | -0.2245284656 |
| GSE48662 | Up | 0.8414458669 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Name | Drug | Accession number |
|---|---|---|
| L-Leucine | DB00149 | NUTR00033 |
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-155-5p | MIMAT0000646 | MIRT020671 | Proteomics | Functional MTI (Weak) | 18668040 |
| hsa-miR-215-5p | MIMAT0000272 | MIRT024901 | Microarray | Functional MTI (Weak) | 19074876 |
| hsa-miR-192-5p | MIMAT0000222 | MIRT026370 | Microarray | Functional MTI (Weak) | 19074876 |
| hsa-miR-21-5p | MIMAT0000076 | MIRT030818 | Microarray | Functional MTI (Weak) | 18591254 |
| hsa-miR-92b-3p | MIMAT0003218 | MIRT040610 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-331-3p | MIMAT0000760 | MIRT043284 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-106b-5p | MIMAT0000680 | MIRT044264 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-183-5p | MIMAT0000261 | MIRT047117 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-92a-3p | MIMAT0000092 | MIRT049782 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
