HCSGD entry for PDE8A
1. General information
| Official gene symbol | PDE8A |
|---|---|
| Entrez ID | 5151 |
| Gene full name | phosphodiesterase 8A |
| Other gene symbols | HsT19550 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000156 | Phosphorelay response regulator activity | IEA | molecular_function |
| GO:0004114 | 3',5'-cyclic-nucleotide phosphodiesterase activity | NAS | molecular_function |
| GO:0004115 | 3',5'-cyclic-AMP phosphodiesterase activity | IEA | molecular_function |
| GO:0005829 | Cytosol | TAS | cellular_component |
| GO:0006198 | CAMP catabolic process | IEA | biological_process |
| GO:0006355 | Regulation of transcription, DNA-templated | IEA | biological_process |
| GO:0009187 | Cyclic nucleotide metabolic process | NAS | biological_process |
| GO:0046872 | Metal ion binding | IEA | molecular_function |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.5718759850 | 0.2046524486 | 0.9999902473 | 0.8768772749 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.1157814481 |
| GSE13712_SHEAR | Down | -0.2118066385 |
| GSE13712_STATIC | Up | 0.1119882677 |
| GSE19018 | Up | 0.1248044813 |
| GSE19899_A1 | Down | -0.4449608354 |
| GSE19899_A2 | Down | -0.0446557057 |
| PubMed_21979375_A1 | Up | 0.4333176917 |
| PubMed_21979375_A2 | Down | -0.2555029065 |
| GSE35957 | Down | -0.1551022723 |
| GSE36640 | Down | -0.5013205534 |
| GSE54402 | Up | 0.3795049961 |
| GSE9593 | Down | -0.0515639735 |
| GSE43922 | Up | 0.2767426876 |
| GSE24585 | Down | -0.3825624318 |
| GSE37065 | Up | 0.2076096818 |
| GSE28863_A1 | Up | 0.1425544687 |
| GSE28863_A2 | Down | -0.0182431065 |
| GSE28863_A3 | Down | -0.6152370471 |
| GSE28863_A4 | Up | 0.1162090187 |
| GSE48662 | Down | -0.3837404521 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-183-5p | MIMAT0000261 | MIRT047034 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
