HCSGD entry for RTCB
1. General information
| Official gene symbol | RTCB |
|---|---|
| Entrez ID | 51493 |
| Gene full name | RNA 2',3'-cyclic phosphate and 5'-OH ligase |
| Other gene symbols | C22orf28 DJ149A16.6 FAAP RP1-149A16.6 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0001701 | In utero embryonic development | IEA | biological_process |
| GO:0001890 | Placenta development | IEA | biological_process |
| GO:0003972 | RNA ligase (ATP) activity | IDA | molecular_function |
| GO:0005524 | ATP binding | IEA | molecular_function |
| GO:0005737 | Cytoplasm | IEA | cellular_component |
| GO:0006388 | TRNA splicing, via endonucleolytic cleavage and ligation | IDA | biological_process |
| GO:0006396 | RNA processing | IEA | biological_process |
| GO:0007160 | Cell-matrix adhesion | NAS | biological_process |
| GO:0008452 | RNA ligase activity | IEA | molecular_function |
| GO:0017166 | Vinculin binding | IPI | molecular_function |
| GO:0034446 | Substrate adhesion-dependent cell spreading | NAS | biological_process |
| GO:0046872 | Metal ion binding | IEA | molecular_function |
| GO:0072669 | TRNA-splicing ligase complex | IDA | cellular_component |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.1192828388 | 0.8137005205 | 0.7079705816 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.6119665040 |
| GSE13712_SHEAR | Down | -0.3282683175 |
| GSE13712_STATIC | Down | -0.0570287919 |
| GSE19018 | Down | -0.0631757278 |
| GSE19899_A1 | Up | 0.2013450867 |
| GSE19899_A2 | Up | 0.1477364634 |
| PubMed_21979375_A1 | Up | 0.6436850383 |
| PubMed_21979375_A2 | Up | 0.0929273615 |
| GSE35957 | Down | -0.2591415572 |
| GSE36640 | Down | -0.2191100390 |
| GSE54402 | Up | 0.3362479469 |
| GSE9593 | Down | -0.0745480998 |
| GSE43922 | Up | 0.1109226284 |
| GSE24585 | Up | 0.0846440058 |
| GSE37065 | Down | -0.3682851533 |
| GSE28863_A1 | Up | 0.3741638194 |
| GSE28863_A2 | Up | 0.4591823807 |
| GSE28863_A3 | Down | -0.2577899124 |
| GSE28863_A4 | Up | 0.2308520618 |
| GSE48662 | Down | -0.1813074142 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Name | Drug | Accession number |
|---|---|---|
| Sucrose | DB02772 | EXPT02977 |
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-26b-5p | MIMAT0000083 | MIRT029675 | Microarray | Functional MTI (Weak) | 19088304 |
| hsa-miR-423-3p | MIMAT0001340 | MIRT042566 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-92a-3p | MIMAT0000092 | MIRT049368 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
