HCSGD entry for UBR5
1. General information
| Official gene symbol | UBR5 |
|---|---|
| Entrez ID | 51366 |
| Gene full name | ubiquitin protein ligase E3 component n-recognin 5 |
| Other gene symbols | DD5 EDD EDD1 HYD |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000209 | Protein polyubiquitination | IDA | biological_process |
| GO:0003723 | RNA binding | IEA | molecular_function |
| GO:0004842 | Ubiquitin-protein ligase activity | IEA TAS | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005634 | Nucleus | IDA | cellular_component |
| GO:0005737 | Cytoplasm | IBA | cellular_component |
| GO:0006281 | DNA repair | IEA | biological_process |
| GO:0006511 | Ubiquitin-dependent protein catabolic process | TAS | biological_process |
| GO:0006974 | Cellular response to DNA damage stimulus | IDA IMP | biological_process |
| GO:0008270 | Zinc ion binding | IEA | molecular_function |
| GO:0008283 | Cell proliferation | TAS | biological_process |
| GO:0033160 | Positive regulation of protein import into nucleus, translocation | IMP | biological_process |
| GO:0034450 | Ubiquitin-ubiquitin ligase activity | IDA | molecular_function |
| GO:0035413 | Positive regulation of catenin import into nucleus | IMP | biological_process |
| GO:0042787 | Protein ubiquitination involved in ubiquitin-dependent protein catabolic process | IBA | biological_process |
| GO:0043130 | Ubiquitin binding | IEA | molecular_function |
| GO:0050847 | Progesterone receptor signaling pathway | IDA | biological_process |
| GO:0090263 | Positive regulation of canonical Wnt signaling pathway | IMP | biological_process |
| GO:1901315 | Negative regulation of histone H2A K63-linked ubiquitination | IMP | biological_process |
| GO:2000780 | Negative regulation of double-strand break repair | IMP | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.7307554538 | 0.0901534934 | 0.9999902473 | 0.5701417828 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.6483799119 |
| GSE13712_SHEAR | Down | -0.0045552305 |
| GSE13712_STATIC | Up | 0.0198108868 |
| GSE19018 | Up | 0.7813791720 |
| GSE19899_A1 | Down | -0.2728233274 |
| GSE19899_A2 | Down | -0.5427976063 |
| PubMed_21979375_A1 | Down | -0.2856794194 |
| PubMed_21979375_A2 | Down | -0.2407535468 |
| GSE35957 | Up | 0.0807394379 |
| GSE36640 | Down | -0.1605741693 |
| GSE54402 | Down | -0.1651659483 |
| GSE9593 | Down | -0.1315514473 |
| GSE43922 | Down | -0.0145771689 |
| GSE24585 | Up | 0.2753940287 |
| GSE37065 | Down | -0.0886255166 |
| GSE28863_A1 | Up | 0.0128128470 |
| GSE28863_A2 | Up | 0.0582948538 |
| GSE28863_A3 | Up | 0.1264107384 |
| GSE28863_A4 | Down | -0.0111882447 |
| GSE48662 | Down | -0.3927608406 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-484 | MIMAT0002174 | MIRT016621 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-1 | MIMAT0000416 | MIRT024039 | Proteomics | Functional MTI (Weak) | 18668040 |
| hsa-miR-93-5p | MIMAT0000093 | MIRT028107 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-21-5p | MIMAT0000076 | MIRT031026 | Microarray | Functional MTI (Weak) | 18591254 |
| hsa-miR-331-3p | MIMAT0000760 | MIRT043427 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 7667101 | We report here an improved version of DD, which we call Enhanced Differential Display (EDD) |
| 7667101 | Using EDD, we have generated and verified a catalog of genes that are differentially expressed between young and senescent human diploid fibroblasts (HDF) |
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