HCSGD entry for PDE1A
1. General information
| Official gene symbol | PDE1A |
|---|---|
| Entrez ID | 5136 |
| Gene full name | phosphodiesterase 1A, calmodulin-dependent |
| Other gene symbols | CAM-PDE-1A HCAM-1 HCAM1 HSPDE1A |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0004115 | 3',5'-cyclic-AMP phosphodiesterase activity | IEA | molecular_function |
| GO:0004117 | Calmodulin-dependent cyclic-nucleotide phosphodiesterase activity | TAS | molecular_function |
| GO:0005516 | Calmodulin binding | IEA | molecular_function |
| GO:0005634 | Nucleus | IEA | cellular_component |
| GO:0005737 | Cytoplasm | IEA | cellular_component |
| GO:0005829 | Cytosol | TAS | cellular_component |
| GO:0006198 | CAMP catabolic process | IEA | biological_process |
| GO:0007165 | Signal transduction | IEA TAS | biological_process |
| GO:0007173 | Epidermal growth factor receptor signaling pathway | TAS | biological_process |
| GO:0007202 | Activation of phospholipase C activity | TAS | biological_process |
| GO:0007596 | Blood coagulation | TAS | biological_process |
| GO:0008543 | Fibroblast growth factor receptor signaling pathway | TAS | biological_process |
| GO:0030553 | CGMP binding | IEA | molecular_function |
| GO:0034391 | Regulation of smooth muscle cell apoptotic process | IEA | biological_process |
| GO:0043025 | Neuronal cell body | IEA | cellular_component |
| GO:0045087 | Innate immune response | TAS | biological_process |
| GO:0046069 | CGMP catabolic process | IEA | biological_process |
| GO:0046872 | Metal ion binding | IEA | molecular_function |
| GO:0048011 | Neurotrophin TRK receptor signaling pathway | TAS | biological_process |
| GO:0048101 | Calcium- and calmodulin-regulated 3',5'-cyclic-GMP phosphodiesterase activity | IEA | molecular_function |
| GO:0048660 | Regulation of smooth muscle cell proliferation | IEA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.2896415562 | 0.2774357357 | 0.9884564631 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.0362974645 |
| GSE13712_SHEAR | Down | -0.0156701124 |
| GSE13712_STATIC | Down | -0.1103387632 |
| GSE19018 | Down | -0.1076416395 |
| GSE19899_A1 | Up | 0.0408189755 |
| GSE19899_A2 | Down | -0.2671703796 |
| PubMed_21979375_A1 | Down | -0.0520998878 |
| PubMed_21979375_A2 | Down | -0.0794653907 |
| GSE35957 | Up | 1.0125043998 |
| GSE36640 | Up | 0.1072682903 |
| GSE54402 | Up | 0.1139075867 |
| GSE9593 | Up | 0.1336752574 |
| GSE43922 | Down | -0.3319472036 |
| GSE24585 | Down | -0.1168970617 |
| GSE37065 | Down | -0.2819048289 |
| GSE28863_A1 | Down | -0.3149199039 |
| GSE28863_A2 | Up | 1.2789250792 |
| GSE28863_A3 | Up | 0.2470118044 |
| GSE28863_A4 | Down | -0.0581368708 |
| GSE48662 | Up | 0.1485882878 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
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- MicroRNAs
- mirTarBase
No target information from mirTarBase
- mirTarBase
- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 26464516 | Senescent human VSMC showed elevated PDE1A and PDE1C and PDE5 mRNA levels (11 |
| 26464516 | Human genetic studies revealed significant associations of PDE1A single nucleotide polymorphisms with diastolic blood pressure (DBP; beta=0 |
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