HCSGD entry for ZBTB7A
1. General information
| Official gene symbol | ZBTB7A |
|---|---|
| Entrez ID | 51341 |
| Gene full name | zinc finger and BTB domain containing 7A |
| Other gene symbols | FBI-1 FBI1 LRF ZBTB7 ZNF857A pokemon |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000122 | Negative regulation of transcription from RNA polymerase II promoter | IEA | biological_process |
| GO:0003677 | DNA binding | ISS | molecular_function |
| GO:0005634 | Nucleus | IEA | cellular_component |
| GO:0006351 | Transcription, DNA-templated | IEA | biological_process |
| GO:0007275 | Multicellular organismal development | IEA | biological_process |
| GO:0030154 | Cell differentiation | IEA | biological_process |
| GO:0035035 | Histone acetyltransferase binding | ISS | molecular_function |
| GO:0045892 | Negative regulation of transcription, DNA-templated | ISS | biological_process |
| GO:0046872 | Metal ion binding | IEA | molecular_function |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.1429121348 | 0.9761713613 | 0.7573163479 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.0294469712 |
| GSE13712_SHEAR | Up | 0.1587754670 |
| GSE13712_STATIC | Up | 0.1711430598 |
| GSE19018 | Down | -0.0379581601 |
| GSE19899_A1 | Up | 0.1024606622 |
| GSE19899_A2 | Up | 0.7966585510 |
| PubMed_21979375_A1 | Up | 0.1504184287 |
| PubMed_21979375_A2 | Up | 0.3068554867 |
| GSE35957 | Up | 0.0673907917 |
| GSE36640 | Up | 0.0324269682 |
| GSE54402 | Up | 0.0589578346 |
| GSE9593 | Up | 0.0692739583 |
| GSE43922 | Up | 0.1145127481 |
| GSE24585 | Down | -0.1548665805 |
| GSE37065 | Up | 0.0425975125 |
| GSE28863_A1 | Up | 0.3111909992 |
| GSE28863_A2 | Up | 0.1226622085 |
| GSE28863_A3 | Up | 0.2111680063 |
| GSE28863_A4 | Up | 0.0511250512 |
| GSE48662 | Up | 0.1106062623 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-222-3p | MIMAT0000279 | MIRT046756 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-93-5p | MIMAT0000093 | MIRT048760 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 23727861 | Zbtb7a suppresses prostate cancer through repression of a Sox9-dependent pathway for cellular senescence bypass and tumor invasion |
| 23727861 | Zbtb7a has previously been described as a powerful proto-oncogene |
| 23727861 | Here we unexpectedly demonstrate that Zbtb7a has a critical oncosuppressive role in the prostate |
| 23727861 | Prostate-specific inactivation of Zbtb7a leads to a marked acceleration of Pten loss-driven prostate tumorigenesis through bypass of Pten loss-induced cellular senescence (PICS) |
| 23727861 | We show that ZBTB7A physically interacts with SOX9 and functionally antagonizes its transcriptional activity on key target genes such as MIA, which is involved in tumor cell invasion, and H19, a long noncoding RNA precursor for an RB-targeting microRNA |
| 23727861 | Inactivation of Zbtb7a in vivo leads to Rb downregulation, PICS bypass and invasive prostate cancer |
| 23727861 | Notably, we found that ZBTB7A is genetically lost, as well as downregulated at both the mRNA and protein levels, in a subset of human advanced prostate cancers |
| 23727861 | Thus, we identify ZBTB7A as a context-dependent cancer gene that can act as an oncogene in some contexts but also has oncosuppressive-like activity in PTEN-null tumors |
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