HCSGD entry for TLR7

1. General information

Official gene symbolTLR7
Entrez ID51284
Gene full nametoll-like receptor 7
Other gene symbolsTLR7-like
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

color bar
This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000139Golgi membraneTAScellular_component
GO:0002224Toll-like receptor signaling pathwayTASbiological_process
GO:0002282Microglial cell activation involved in immune responseIEAbiological_process
GO:0002755MyD88-dependent toll-like receptor signaling pathwayIEAbiological_process
GO:0003725Double-stranded RNA bindingIDAmolecular_function
GO:0003727Single-stranded RNA bindingISSmolecular_function
GO:0004888Transmembrane signaling receptor activityIEAmolecular_function
GO:0005737CytoplasmIDAcellular_component
GO:0005764LysosomeISScellular_component
GO:0005768EndosomeISScellular_component
GO:0005783Endoplasmic reticulumISScellular_component
GO:0005789Endoplasmic reticulum membraneTAScellular_component
GO:0005886Plasma membraneIDAcellular_component
GO:0006954Inflammatory responseIEAbiological_process
GO:0007252I-kappaB phosphorylationIDAbiological_process
GO:0008144Drug bindingIEAmolecular_function
GO:0010008Endosome membraneTAScellular_component
GO:0016021Integral component of membraneIEAcellular_component
GO:0032009Early phagosomeISScellular_component
GO:0032722Positive regulation of chemokine productionIDAbiological_process
GO:0032755Positive regulation of interleukin-6 productionIEAbiological_process
GO:0032757Positive regulation of interleukin-8 productionIDAbiological_process
GO:0034154Toll-like receptor 7 signaling pathwayIEAbiological_process
GO:0034162Toll-like receptor 9 signaling pathwayTASbiological_process
GO:0035197SiRNA bindingISSmolecular_function
GO:0036020Endolysosome membraneTAScellular_component
GO:0042346Positive regulation of NF-kappaB import into nucleusIDAbiological_process
GO:0043235Receptor complexIDAcellular_component
GO:0045078Positive regulation of interferon-gamma biosynthetic processIDAbiological_process
GO:0045087Innate immune responseTASbiological_process
GO:0045356Positive regulation of interferon-alpha biosynthetic processIDAbiological_process
GO:0045359Positive regulation of interferon-beta biosynthetic processIDAbiological_process
GO:0045416Positive regulation of interleukin-8 biosynthetic processIMPbiological_process
GO:0050729Positive regulation of inflammatory responseICbiological_process
GO:0051607Defense response to virusIMPbiological_process
GO:0052033Pathogen-associated molecular pattern dependent induction by symbiont of host innate immune responseIEAbiological_process
GO:0071260Cellular response to mechanical stimulusIEPbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.53161946350.95981042890.99999024731.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.0556214929
GSE13712_SHEARDown-0.1017734036
GSE13712_STATICUp0.0738799405
GSE19018Up0.1219733398
GSE19899_A1Up0.1125691254
GSE19899_A2Up0.1470757713
PubMed_21979375_A1Up0.1402843652
PubMed_21979375_A2Up0.0010542359
GSE35957Up0.1252554132
GSE36640Up0.1539882648
GSE54402Up0.0842492621
GSE9593Up0.0504776890
GSE43922Up0.0162781793
GSE24585Up0.1131134321
GSE37065Up0.0485918097
GSE28863_A1--
GSE28863_A2--
GSE28863_A3--
GSE28863_A4--
GSE48662Up0.0159621824

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

ImiquimodDB00724 APRD01030
IsatoribineDB04860 -
ANA971DB05127 -
SCV-07DB05475 -

  • MicroRNAs

    • mirTarBase
No target information from mirTarBase
    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.