HCSGD entry for NT5C3A
1. General information
| Official gene symbol | NT5C3A |
|---|---|
| Entrez ID | 51251 |
| Gene full name | 5'-nucleotidase, cytosolic IIIA |
| Other gene symbols | NT5C3 P5'N-1 P5N-1 PN-I POMP PSN1 UMPH UMPH1 cN-III hUMP1 p36 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000166 | Nucleotide binding | IEA | molecular_function |
| GO:0000287 | Magnesium ion binding | IEA NAS | molecular_function |
| GO:0005737 | Cytoplasm | IDA IEA | cellular_component |
| GO:0005739 | Mitochondrion | IEA | cellular_component |
| GO:0005783 | Endoplasmic reticulum | IDA | cellular_component |
| GO:0005829 | Cytosol | TAS | cellular_component |
| GO:0006206 | Pyrimidine nucleobase metabolic process | TAS | biological_process |
| GO:0006213 | Pyrimidine nucleoside metabolic process | NAS | biological_process |
| GO:0008253 | 5'-nucleotidase activity | EXP IDA IEA NAS | molecular_function |
| GO:0008665 | 2'-phosphotransferase activity | NAS TAS | molecular_function |
| GO:0009117 | Nucleotide metabolic process | IEA | biological_process |
| GO:0016311 | Dephosphorylation | EXP IDA NAS | biological_process |
| GO:0044281 | Small molecule metabolic process | TAS | biological_process |
| GO:0046085 | Adenosine metabolic process | IEA | biological_process |
| GO:0046135 | Pyrimidine nucleoside catabolic process | TAS | biological_process |
| GO:0055086 | Nucleobase-containing small molecule metabolic process | TAS | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.0306377531 | 0.7188644086 | 0.4046243352 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.3901394532 |
| GSE13712_SHEAR | Up | 0.2668144261 |
| GSE13712_STATIC | Up | 0.4326969294 |
| GSE19018 | Down | -0.7328835898 |
| GSE19899_A1 | Up | 0.5099763556 |
| GSE19899_A2 | Up | 0.1036902898 |
| PubMed_21979375_A1 | Up | 1.0750152141 |
| PubMed_21979375_A2 | Up | 0.6641163087 |
| GSE35957 | Down | -0.4755664954 |
| GSE36640 | Up | 0.5661271850 |
| GSE54402 | Up | 0.3258533132 |
| GSE9593 | Down | -0.0242451908 |
| GSE43922 | Up | 0.0556334649 |
| GSE24585 | Up | 0.1844548696 |
| GSE37065 | Up | 0.8027684216 |
| GSE28863_A1 | Up | 0.2015075418 |
| GSE28863_A2 | Up | 0.2434296036 |
| GSE28863_A3 | Down | -0.3318985326 |
| GSE28863_A4 | Down | -0.2858424118 |
| GSE48662 | Down | -0.3241826758 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-30a-5p | MIMAT0000087 | MIRT005184 | pSILAC//Proteomics;Other | Functional MTI (Weak) | 18668040 |
| hsa-miR-122-5p | MIMAT0000421 | MIRT007081 | Luciferase reporter assay | Functional MTI | 23055569 |
| hsa-miR-16-5p | MIMAT0000069 | MIRT031382 | Proteomics | Functional MTI (Weak) | 18668040 |
| hsa-miR-320a | MIMAT0000510 | MIRT044479 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 3 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 26284488 | In this paper we examined if senescent HPMCs can intensify the progression of colorectal (SW480) and pancreatic (PSN-1) cancers in vitro and in vivo |
| 19904754 | Intercellular adhesion molecule-1 (ICAM-1) has been implicated in adhesion of colorectal and pancreatic cancer cells (of the SW480 and PSN-1 line, respectively) to the peritoneal mesothelium |
| 1805604 | 1b protein ratio, the stability of a number of glycolytic enzymes, and the instability of pyrimidine 5'-nucleotidase activity |
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