HCSGD entry for ABI3

1. General information

Official gene symbolABI3
Entrez ID51225
Gene full nameABI family, member 3
Other gene symbolsNESH SSH3BP3
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

color bar
This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0005515Protein bindingIPImolecular_function
GO:0005622IntracellularIDAcellular_component
GO:0005737CytoplasmIDA NAScellular_component
GO:0006928Cellular component movementNASbiological_process
GO:0018108Peptidyl-tyrosine phosphorylationIDAbiological_process
GO:0030027LamellipodiumIDAcellular_component
GO:0030334Regulation of cell migrationIDAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.69957577600.13621517040.99999024730.7115929776

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.1317500499
GSE13712_SHEARDown-0.1608483359
GSE13712_STATICDown-0.0294362263
GSE19018Up0.0994268716
GSE19899_A1Down-0.0036776823
GSE19899_A2Down-0.0636266314
PubMed_21979375_A1Down-0.4110772209
PubMed_21979375_A2Down-0.1332546034
GSE35957Up0.1438937367
GSE36640Down-0.9213318157
GSE54402Down-0.4032447600
GSE9593Up0.2112311293
GSE43922Up0.0309371627
GSE24585Down-0.0706824377
GSE37065Up0.1711467520
GSE28863_A1Down-0.4706472910
GSE28863_A2Down-0.3866129474
GSE28863_A3Up0.3218617727
GSE28863_A4Up0.4465526422
GSE48662Up0.0217091158

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-744-5pMIMAT0004945MIRT037451CLASHFunctional MTI (Weak)23622248
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    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

21223585ABI3 ectopic expression reduces in vitro and in vivo cell growth properties while inducing senescence
21223585BACKGROUND: Mounting evidence has indicated that ABI3 (ABI family member 3) function as a tumor suppressor gene, although the molecular mechanism by which ABI3 acts remains largely unknown
21223585METHODS: The present study investigated ABI3 expression in a large panel of benign and malignant thyroid tumors and explored a correlation between the expression of ABI3 and its potential partner ABI3-binding protein (ABI3BP)
21223585We next explored the biological effects of ABI3 ectopic expression in thyroid and colon carcinoma cell lines, in which its expression was reduced or absent
21223585RESULTS: We not only observed that ABI3 expression is reduced or lost in most carcinomas but also that there is a positive correlation between ABI3 and ABI3BP expression
21223585Ectopic expression of ABI3 was sufficient to lead to a lower transforming activity, reduced tumor in vitro growth properties, suppressed in vitro anchorage-independent growth and in vivo tumor formation while, cellular senescence increased
21223585CONCLUSIONS: Our result links ABI3 to the pathogenesis and progression of some cancers and suggests that ABI3 or its pathway might have interest as therapeutic target
21223585These results also suggest that the pathways through which ABI3 works should be further characterized
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