HCSGD entry for ING4

1. General information

Official gene symbolING4
Entrez ID51147
Gene full nameinhibitor of growth family, member 4
Other gene symbolsmy036 p29ING4
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

color bar
This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000123Histone acetyltransferase complexIDAcellular_component
GO:0003713Transcription coactivator activityIDAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005634NucleusIDAcellular_component
GO:0006260DNA replicationIDAbiological_process
GO:0006473Protein acetylationIDAbiological_process
GO:0006915Apoptotic processIDAbiological_process
GO:0006978DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediatorIDAbiological_process
GO:0007050Cell cycle arrestIDAbiological_process
GO:0008270Zinc ion bindingIEAmolecular_function
GO:0008285Negative regulation of cell proliferationIDAbiological_process
GO:0035064Methylated histone residue bindingIDAmolecular_function
GO:0043065Positive regulation of apoptotic processIDAbiological_process
GO:0043966Histone H3 acetylationIDAbiological_process
GO:0043981Histone H4-K5 acetylationIDAbiological_process
GO:0043982Histone H4-K8 acetylationIDAbiological_process
GO:0043983Histone H4-K12 acetylationIDAbiological_process
GO:0043984Histone H4-K16 acetylationIDAbiological_process
GO:0045892Negative regulation of transcription, DNA-templatedIDAbiological_process
GO:0045926Negative regulation of growthIDAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.25786041940.38159871590.95131195521.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.0798069227
GSE13712_SHEARDown-0.4326882308
GSE13712_STATICDown-0.2540308637
GSE19018Up0.1175524729
GSE19899_A1Down-0.0507477379
GSE19899_A2Up0.1921273823
PubMed_21979375_A1Down-0.4237554578
PubMed_21979375_A2Down-0.1352280329
GSE35957Up0.4776134066
GSE36640Up0.4200257885
GSE54402Up0.0449673917
GSE9593Up0.2417948106
GSE43922Down-0.2481295248
GSE24585Up0.6491449854
GSE37065Down-0.0532237290
GSE28863_A1Up0.3961819761
GSE28863_A2Up0.0226027643
GSE28863_A3Down-0.3720223427
GSE28863_A4Down-0.0085085901
GSE48662Up0.3526991116

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-650MIMAT0003320MIRT000448Luciferase reporter assay//qRT-PCR//Western blotFunctional MTI20381459
hsa-miR-335-5pMIMAT0000765MIRT017117MicroarrayFunctional MTI (Weak)18185580
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    • mirRecord

MicroRNA name

mirBase ID

Target site number

MiRNA mature ID

Test method inter

MiRNA regulation site

Reporter target site

Pubmed ID

hsa-miR-650MIMAT00033201hsa-miR-650{Western blot}{overexpression by miRNA precursor transfection}20381459
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6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

21767350While ING1, ING2 and ING3 proteins are stable components of the mSIN3a-HDAC complexes, the association of ING1, ING4 and ING5 with HAT protein complexes was also reported
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