HCSGD entry for NDUFA13
1. General information
| Official gene symbol | NDUFA13 |
|---|---|
| Entrez ID | 51079 |
| Gene full name | NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 13 |
| Other gene symbols | B16.6 CDA016 GRIM-19 GRIM19 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0003954 | NADH dehydrogenase activity | IMP | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005524 | ATP binding | NAS | molecular_function |
| GO:0005654 | Nucleoplasm | IDA | cellular_component |
| GO:0005737 | Cytoplasm | IDA | cellular_component |
| GO:0005739 | Mitochondrion | IDA | cellular_component |
| GO:0005743 | Mitochondrial inner membrane | TAS | cellular_component |
| GO:0005746 | Mitochondrial respiratory chain | IDA | cellular_component |
| GO:0005747 | Mitochondrial respiratory chain complex I | IDA | cellular_component |
| GO:0006606 | Protein import into nucleus | NAS | biological_process |
| GO:0008137 | NADH dehydrogenase (ubiquinone) activity | IDA | molecular_function |
| GO:0016021 | Integral component of membrane | IEA | cellular_component |
| GO:0017148 | Negative regulation of translation | IDA | biological_process |
| GO:0022904 | Respiratory electron transport chain | TAS | biological_process |
| GO:0030262 | Apoptotic nuclear changes | IDA | biological_process |
| GO:0030308 | Negative regulation of cell growth | IDA IMP | biological_process |
| GO:0031966 | Mitochondrial membrane | IDA | cellular_component |
| GO:0044237 | Cellular metabolic process | TAS | biological_process |
| GO:0044281 | Small molecule metabolic process | TAS | biological_process |
| GO:0045892 | Negative regulation of transcription, DNA-templated | IDA | biological_process |
| GO:0072593 | Reactive oxygen species metabolic process | IMP | biological_process |
| GO:0097190 | Apoptotic signaling pathway | IDA | biological_process |
| GO:0097191 | Extrinsic apoptotic signaling pathway | IEA | biological_process |
| GO:2001243 | Negative regulation of intrinsic apoptotic signaling pathway | IMP | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.2218686866 | 0.6055254474 | 0.9031558460 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.4034160947 |
| GSE13712_SHEAR | Down | -0.3090644907 |
| GSE13712_STATIC | Down | -0.1832500286 |
| GSE19018 | Up | 0.2692806408 |
| GSE19899_A1 | Down | -0.0244955614 |
| GSE19899_A2 | Up | 0.1899002457 |
| PubMed_21979375_A1 | Up | 0.7112037895 |
| PubMed_21979375_A2 | Up | 0.3723347244 |
| GSE35957 | Down | -0.1675430622 |
| GSE36640 | Up | 0.4138516958 |
| GSE54402 | Up | 0.1816753938 |
| GSE9593 | Up | 0.1350529603 |
| GSE43922 | Up | 0.3576113209 |
| GSE24585 | Down | -0.0255420280 |
| GSE37065 | Down | -0.2446576950 |
| GSE28863_A1 | Down | -0.2318748691 |
| GSE28863_A2 | Down | -0.4732623075 |
| GSE28863_A3 | Up | 0.0787222557 |
| GSE28863_A4 | Up | 0.1076995155 |
| GSE48662 | Down | -0.0155717183 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Name | Drug | Accession number |
|---|---|---|
| NADH | DB00157 | NUTR00041 | DB01907 | EXPT02287 | DB03527 |
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-484 | MIMAT0002174 | MIRT042006 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 27142689 | GRIM-19 Restores Cervical Cancer Cell Senescence by Repressing hTERT Transcription |
| 27142689 | GRIM-19 is a novel tumor suppressor that affects multiple targets in a cell to regulate growth |
| 27142689 | We have previously reported the interaction of GRIM-19 with 18E6 and E6AP to disrupt the E6/E6AP complex and increase the autoubiquitination of E6AP |
| 27142689 | In this study, we characterized the interaction of GRIM-19 with 16E6 (an oncoprotein produced by HPV16) and identified the binding sites that mediate this interaction |
| 27142689 | We also found that GRIM-19 expression in cervical cancer cells could inhibit telomerase activity by inhibiting the transactivation of the hTERT promoter by E6, thereby promoting cervical cancer cell senescence |
| 27142689 | Moreover, we identified a negative correlation between GRIM-19 and hTERT expression in cervical cancer tissues |
| 27142689 | Suppression of GRIM-19 and induction of hTERT levels were associated with lymph node metastasis, advanced clinical stage, and poor prognosis |
| 27142689 | This study identified another important novel antitumor molecular link associated with GRIM-19 in the tumorigenesis |
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