HCSGD entry for EXOSC3

1. General information

Official gene symbolEXOSC3
Entrez ID51010
Gene full nameexosome component 3
Other gene symbolsPCH1B RP11-3J10.8 RRP40 Rrp40p bA3J10.7 hRrp-40 p10
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:00001753'-5'-exoribonuclease activityNASmolecular_function
GO:0000176Nuclear exosome (RNase complex)IDAcellular_component
GO:0000177Cytoplasmic exosome (RNase complex)IDAcellular_component
GO:0000178Exosome (RNase complex)IDAcellular_component
GO:0000288Nuclear-transcribed mRNA catabolic process, deadenylation-dependent decayTASbiological_process
GO:0003723RNA bindingIEAmolecular_function
GO:0004532Exoribonuclease activityIDAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005634NucleusIDAcellular_component
GO:0005730NucleolusIDAcellular_component
GO:0005737CytoplasmIDAcellular_component
GO:0005829CytosolTAScellular_component
GO:0006364RRNA processingIDAbiological_process
GO:0010467Gene expressionTASbiological_process
GO:0016070RNA metabolic processTASbiological_process
GO:0016071MRNA metabolic processTASbiological_process
GO:0035327Transcriptionally active chromatinIMPcellular_component
GO:0043928Exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decayIMP TASbiological_process
GO:0045006DNA deaminationIDAbiological_process
GO:0045190Isotype switchingISSbiological_process
GO:0045830Positive regulation of isotype switchingIEAbiological_process
GO:0071034CUT catabolic processIMPbiological_process
GO:0090305Nucleic acid phosphodiester bond hydrolysisNASbiological_process
GO:0090501RNA phosphodiester bond hydrolysisNASbiological_process
GO:0090503RNA phosphodiester bond hydrolysis, exonucleolyticNASbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.41625439000.26735475860.99999024730.9890435137

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.1601888710
GSE13712_SHEARUp0.4199853780
GSE13712_STATICUp0.1490976731
GSE19018Down-0.2925064260
GSE19899_A1Up0.1672775333
GSE19899_A2Down-0.0288161611
PubMed_21979375_A1Up0.2801279288
PubMed_21979375_A2Down-0.3873725351
GSE35957Down-0.1660104198
GSE36640Down-0.5783253569
GSE54402Up0.3729509001
GSE9593Down-0.4389352578
GSE43922Up0.0420813250
GSE24585Down-0.3272825915
GSE37065Down-0.0507416819
GSE28863_A1Up0.3225819562
GSE28863_A2Up0.0829998475
GSE28863_A3Down-0.0635504567
GSE28863_A4Up0.1287473209
GSE48662Down-0.4943770593

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

    • mirTarBase
No target information from mirTarBase
    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.