HCSGD entry for SOST
1. General information
| Official gene symbol | SOST |
|---|---|
| Entrez ID | 50964 |
| Gene full name | sclerostin |
| Other gene symbols | CDD VBCH |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0001503 | Ossification | IEA | biological_process |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005578 | Proteinaceous extracellular matrix | IEA | cellular_component |
| GO:0005615 | Extracellular space | IEA | cellular_component |
| GO:0005794 | Golgi apparatus | IEA | cellular_component |
| GO:0008134 | Transcription factor binding | IDA | molecular_function |
| GO:0008201 | Heparin binding | IEA | molecular_function |
| GO:0009612 | Response to mechanical stimulus | IEP | biological_process |
| GO:0016055 | Wnt signaling pathway | IEA | biological_process |
| GO:0030279 | Negative regulation of ossification | NAS | biological_process |
| GO:0030514 | Negative regulation of BMP signaling pathway | IDA | biological_process |
| GO:0031012 | Extracellular matrix | IDA | cellular_component |
| GO:0031333 | Negative regulation of protein complex assembly | IDA | biological_process |
| GO:0045893 | Positive regulation of transcription, DNA-templated | IMP | biological_process |
| GO:0071374 | Cellular response to parathyroid hormone stimulus | IDA | biological_process |
| GO:0090090 | Negative regulation of canonical Wnt signaling pathway | IDA | biological_process |
| GO:2000054 | Negative regulation of Wnt signaling pathway involved in dorsal/ventral axis specification | IDA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.4144712511 | 0.7585198093 | 0.9999902473 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.2031655014 |
| GSE13712_SHEAR | Up | 0.0573235100 |
| GSE13712_STATIC | Down | -0.1998057457 |
| GSE19018 | Up | 0.1172836168 |
| GSE19899_A1 | Up | 0.1077193267 |
| GSE19899_A2 | Down | -0.0841738843 |
| PubMed_21979375_A1 | Up | 0.2857586391 |
| PubMed_21979375_A2 | Up | 0.0192286993 |
| GSE35957 | Up | 0.3568205109 |
| GSE36640 | Up | 0.0442427905 |
| GSE54402 | Up | 0.0662140268 |
| GSE9593 | Down | -0.0633667725 |
| GSE43922 | Up | 0.1724818589 |
| GSE24585 | Up | 0.1656327845 |
| GSE37065 | Down | -0.2873426274 |
| GSE28863_A1 | Down | -0.0215539042 |
| GSE28863_A2 | Down | -0.1111688215 |
| GSE28863_A3 | Up | 0.2177233622 |
| GSE28863_A4 | Up | 0.0514294961 |
| GSE48662 | Up | 0.1686716771 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-218-5p | MIMAT0000275 | MIRT006748 | Luciferase reporter assay | Functional MTI | 23060446 |
| hsa-miR-204-5p | MIMAT0000265 | MIRT007117 | Luciferase reporter assay | Functional MTI | 23472141 |
| hsa-miR-335-5p | MIMAT0000765 | MIRT018098 | Microarray | Functional MTI (Weak) | 18185580 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 2 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 27188231 | Morc3(mut +/-) mice displayed reduced osteoclast numbers and surface per bone surface as well as osteocyte numbers, concomitant with altered gene expressions such as Rankl/Opg and Sost in ex vivo long bones |
| 24286133 | We also examined whether the inhibition of Wnt signaling using cotransfection with Dickkopf (DKK) isoforms and Sclerostin (SOST) could block the effects of pathological TNF-alpha expression in nucleus pulposus cells |
| 24286133 | Moreover, transfection with DKK-3, DKK-4, or SOST, which are inhibitors of Wnt signaling, blocked Wnt signaling-mediated TNF-alpha activation; these effects were not observed for DKK-1 or DKK-2 |
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