HCSGD entry for PCBP2
1. General information
| Official gene symbol | PCBP2 |
|---|---|
| Entrez ID | 5094 |
| Gene full name | poly(rC) binding protein 2 |
| Other gene symbols | HNRPE2 hnRNP-E2 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000398 | MRNA splicing, via spliceosome | TAS | biological_process |
| GO:0003677 | DNA binding | IEA | molecular_function |
| GO:0003723 | RNA binding | IDA IEA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005634 | Nucleus | IDA | cellular_component |
| GO:0005654 | Nucleoplasm | TAS | cellular_component |
| GO:0005730 | Nucleolus | IDA | cellular_component |
| GO:0005737 | Cytoplasm | IDA | cellular_component |
| GO:0005829 | Cytosol | TAS | cellular_component |
| GO:0008380 | RNA splicing | TAS | biological_process |
| GO:0010467 | Gene expression | TAS | biological_process |
| GO:0016071 | MRNA metabolic process | NAS | biological_process |
| GO:0019899 | Enzyme binding | IPI | molecular_function |
| GO:0030529 | Ribonucleoprotein complex | IEA | cellular_component |
| GO:0031625 | Ubiquitin protein ligase binding | IPI | molecular_function |
| GO:0032480 | Negative regulation of type I interferon production | TAS | biological_process |
| GO:0043161 | Proteasome-mediated ubiquitin-dependent protein catabolic process | IMP | biological_process |
| GO:0045087 | Innate immune response | TAS | biological_process |
| GO:0050687 | Negative regulation of defense response to virus | IMP | biological_process |
| GO:0051607 | Defense response to virus | IEA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.8857300065 | 0.0870117169 | 0.9999902473 | 0.5595493281 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.3018730548 |
| GSE13712_SHEAR | Down | -0.3235332712 |
| GSE13712_STATIC | Down | -0.4077007648 |
| GSE19018 | Down | -0.2927896644 |
| GSE19899_A1 | Down | -0.1706073452 |
| GSE19899_A2 | Down | -0.2147886827 |
| PubMed_21979375_A1 | Down | -0.6827786892 |
| PubMed_21979375_A2 | Up | 0.2501297533 |
| GSE35957 | Down | -0.1216712232 |
| GSE36640 | Down | -0.0652678627 |
| GSE54402 | Down | -0.0328807507 |
| GSE9593 | Down | -0.1692296421 |
| GSE43922 | Down | -0.1570090065 |
| GSE24585 | Up | 0.2204022482 |
| GSE37065 | Down | -0.3330687687 |
| GSE28863_A1 | Up | 0.3812736806 |
| GSE28863_A2 | Up | 0.2873581993 |
| GSE28863_A3 | Up | 0.0413320701 |
| GSE28863_A4 | Up | 0.1950650097 |
| GSE48662 | Down | -0.2047672284 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-615-3p | MIMAT0003283 | MIRT040061 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-320a | MIMAT0000510 | MIRT044663 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-125b-5p | MIMAT0000423 | MIRT046036 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-222-3p | MIMAT0000279 | MIRT046688 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-100-5p | MIMAT0000098 | MIRT048457 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-92a-3p | MIMAT0000092 | MIRT049623 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-let-7e-5p | MIMAT0000066 | MIRT051448 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-let-7b-5p | MIMAT0000063 | MIRT052216 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 26907686 | RNA-binding Protein PCBP2 Regulates p73 Expression and p73-dependent Antioxidant Defense |
| 26907686 | Here, we showed that TAp73 activity is regulated by RNA-binding protein PCBP2 |
| 26907686 | Specifically, we found that knockdown or knock-out of PCBP2 reduces, whereas ectopic expression of PCBP2 increases, TAp73 expression |
| 26907686 | We also showed that PCBP2 is necessary for p73 mRNA stability via the CU-rich elements in p73 3'-UTR |
| 26907686 | To uncover the biological relevance of PCBP2-regulated TAp73 expression, we showed that ectopic expression of PCBP2 inhibits, whereas knockdown or knock-out of PCBP2 increases, the production of reactive oxygen species (ROS) in a TAp73-dependent manner |
| 26907686 | Moreover, we generated PCBP2-deficient mice and primary mouse embryonic fibroblasts (MEFs) and showed that loss of PCBP2 leads to decreased p73 expression and, subsequently, increased ROS production and accelerated cellular senescence |
| 26907686 | Together, our data suggest that PCBP2 regulates p73 expression via mRNA stability and p73-dependent biological function in ROS production and cellular senescence |
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