HCSGD entry for PAX6

1. General information

Official gene symbolPAX6
Entrez ID5080
Gene full namepaired box 6
Other gene symbolsAN AN2 D11S812E MGDA WAGR
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

color bar
This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000790Nuclear chromatinIDA IEAcellular_component
GO:0000979RNA polymerase II core promoter sequence-specific DNA bindingIDA IEAmolecular_function
GO:0000981Sequence-specific DNA binding RNA polymerase II transcription factor activityIDA IEAmolecular_function
GO:0001568Blood vessel developmentIMPbiological_process
GO:0001654Eye developmentTASbiological_process
GO:0001709Cell fate determinationIEAbiological_process
GO:0001764Neuron migrationIEAbiological_process
GO:0002052Positive regulation of neuroblast proliferationIEAbiological_process
GO:0002088Lens development in camera-type eyeIEAbiological_process
GO:0003309Type B pancreatic cell differentiationIEAbiological_process
GO:0003322Pancreatic A cell developmentIEA IMPbiological_process
GO:0003677DNA bindingIEA TASmolecular_function
GO:0003680AT DNA bindingIEAmolecular_function
GO:0003690Double-stranded DNA bindingIEAmolecular_function
GO:0003700Sequence-specific DNA binding transcription factor activityTASmolecular_function
GO:0004842Ubiquitin-protein ligase activityISSmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005634NucleusIDA IEAcellular_component
GO:0005730NucleolusIDAcellular_component
GO:0005737CytoplasmIDAcellular_component
GO:0006351Transcription, DNA-templatedIEAbiological_process
GO:0006355Regulation of transcription, DNA-templatedIEAbiological_process
GO:0006366Transcription from RNA polymerase II promoterIMPbiological_process
GO:0007224Smoothened signaling pathwayIEAbiological_process
GO:0007275Multicellular organismal developmentIEAbiological_process
GO:0007411Axon guidanceIEAbiological_process
GO:0007417Central nervous system developmentTASbiological_process
GO:0007435Salivary gland morphogenesisIEAbiological_process
GO:0007601Visual perceptionTASbiological_process
GO:0008134Transcription factor bindingIEA ISSmolecular_function
GO:0009611Response to woundingIEPbiological_process
GO:0009887Organ morphogenesisTASbiological_process
GO:0009950Dorsal/ventral axis specificationIEAbiological_process
GO:0010628Positive regulation of gene expressionIMPbiological_process
GO:0016567Protein ubiquitinationISSbiological_process
GO:0019901Protein kinase bindingIEA ISSmolecular_function
GO:0021778Oligodendrocyte cell fate specificationIEAbiological_process
GO:0021796Cerebral cortex regionalizationIEAbiological_process
GO:0021797Forebrain anterior/posterior pattern specificationIEAbiological_process
GO:0021798Forebrain dorsal/ventral pattern formationIEAbiological_process
GO:0021902Commitment of neuronal cell to specific neuron type in forebrainIEAbiological_process
GO:0021905Forebrain-midbrain boundary formationIEAbiological_process
GO:0021912Regulation of transcription from RNA polymerase II promoter involved in spinal cord motor neuron fate specificationIEAbiological_process
GO:0021913Regulation of transcription from RNA polymerase II promoter involved in ventral spinal cord interneuron specificationIEAbiological_process
GO:0021918Regulation of transcription from RNA polymerase II promoter involved in somatic motor neuron fate commitmentIEAbiological_process
GO:0021983Pituitary gland developmentIEAbiological_process
GO:0023019Signal transduction involved in regulation of gene expressionIEAbiological_process
GO:0030216Keratinocyte differentiationIEAbiological_process
GO:0030334Regulation of cell migrationIEAbiological_process
GO:0030858Positive regulation of epithelial cell differentiationIEAbiological_process
GO:0030902Hindbrain developmentIEAbiological_process
GO:0031625Ubiquitin protein ligase bindingIEAmolecular_function
GO:0032808Lacrimal gland developmentIEAbiological_process
GO:0033365Protein localization to organelleIEAbiological_process
GO:0035035Histone acetyltransferase bindingIEA ISSmolecular_function
GO:0042462Eye photoreceptor cell developmentIEAbiological_process
GO:0042593Glucose homeostasisIMPbiological_process
GO:0042660Positive regulation of cell fate specificationIEAbiological_process
GO:0045665Negative regulation of neuron differentiationIEAbiological_process
GO:0045893Positive regulation of transcription, DNA-templatedIMPbiological_process
GO:0045944Positive regulation of transcription from RNA polymerase II promoterIEA ISSbiological_process
GO:0048505Regulation of timing of cell differentiationIEAbiological_process
GO:0048596Embryonic camera-type eye morphogenesisIEAbiological_process
GO:0048663Neuron fate commitmentNASbiological_process
GO:0048708Astrocyte differentiationIEAbiological_process
GO:0050680Negative regulation of epithelial cell proliferationIEAbiological_process
GO:0050768Negative regulation of neurogenesisISSbiological_process
GO:0061072Iris morphogenesisIMPbiological_process
GO:0061303Cornea development in camera-type eyeIMPbiological_process
GO:0070410Co-SMAD bindingIEAmolecular_function
GO:0070412R-SMAD bindingIEA IPImolecular_function
GO:0071837HMG box domain bindingIEAmolecular_function
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.30496264580.88724701570.99999024731.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.1394193372
GSE13712_SHEARDown-0.0095578125
GSE13712_STATICDown-0.1387485414
GSE19018Down-0.0364573373
GSE19899_A1Up0.2082900750
GSE19899_A2Down-0.0913272105
PubMed_21979375_A1Up0.1344468612
PubMed_21979375_A2Up0.1441934747
GSE35957Up0.2060486326
GSE36640Up0.2089780533
GSE54402Up0.0265256346
GSE9593Up0.0912984529
GSE43922Up0.0023805639
GSE24585Up0.0107040292
GSE37065Down-0.0864690845
GSE28863_A1Down-0.1482354896
GSE28863_A2Down-0.0366691521
GSE28863_A3Up0.1540470748
GSE28863_A4Up0.4188169346
GSE48662Up0.0404045035

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-10b-5pMIMAT0000254MIRT006925Luciferase reporter assayFunctional MTI23034333
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    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.