HCSGD entry for PAWR
1. General information
| Official gene symbol | PAWR |
|---|---|
| Entrez ID | 5074 |
| Gene full name | PRKC, apoptosis, WT1, regulator |
| Other gene symbols | PAR4 Par-4 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000122 | Negative regulation of transcription from RNA polymerase II promoter | TAS | biological_process |
| GO:0003714 | Transcription corepressor activity | TAS | molecular_function |
| GO:0003779 | Actin binding | ISS | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005634 | Nucleus | IDA IEA | cellular_component |
| GO:0005737 | Cytoplasm | IDA IEA | cellular_component |
| GO:0005884 | Actin filament | ISS | cellular_component |
| GO:0005886 | Plasma membrane | IDA | cellular_component |
| GO:0006351 | Transcription, DNA-templated | IEA | biological_process |
| GO:0006915 | Apoptotic process | IEA ISS | biological_process |
| GO:0008285 | Negative regulation of cell proliferation | TAS | biological_process |
| GO:0019899 | Enzyme binding | IDA | molecular_function |
| GO:0030889 | Negative regulation of B cell proliferation | IEA | biological_process |
| GO:0042094 | Interleukin-2 biosynthetic process | IEA | biological_process |
| GO:0042130 | Negative regulation of T cell proliferation | IEA | biological_process |
| GO:0042986 | Positive regulation of amyloid precursor protein biosynthetic process | IEA | biological_process |
| GO:0043065 | Positive regulation of apoptotic process | NAS | biological_process |
| GO:0043522 | Leucine zipper domain binding | IPI | molecular_function |
| GO:0050860 | Negative regulation of T cell receptor signaling pathway | IEA | biological_process |
| GO:0051017 | Actin filament bundle assembly | ISS | biological_process |
| GO:0097190 | Apoptotic signaling pathway | IEA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.9263458189 | 0.0013983283 | 0.9999902473 | 0.0723092338 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -1.2362296002 |
| GSE13712_SHEAR | Up | 0.0641746594 |
| GSE13712_STATIC | Up | 0.5014426333 |
| GSE19018 | Down | -0.1023479593 |
| GSE19899_A1 | Down | -0.9462850922 |
| GSE19899_A2 | Down | -1.7199073499 |
| PubMed_21979375_A1 | Down | -1.8939621016 |
| PubMed_21979375_A2 | Down | -2.3561276420 |
| GSE35957 | Up | 0.5768060900 |
| GSE36640 | Up | 0.0904705086 |
| GSE54402 | Down | -1.1921864568 |
| GSE9593 | Up | 0.1081621930 |
| GSE43922 | Down | -1.0386554892 |
| GSE24585 | Down | -0.1338770531 |
| GSE37065 | Down | -0.2244418652 |
| GSE28863_A1 | Down | -0.6229791027 |
| GSE28863_A2 | Down | -0.6140172252 |
| GSE28863_A3 | Down | -0.3154668339 |
| GSE28863_A4 | Down | -0.0335902824 |
| GSE48662 | Up | 0.6025061696 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-215-5p | MIMAT0000272 | MIRT024766 | Microarray | Functional MTI (Weak) | 19074876 |
| hsa-miR-192-5p | MIMAT0000222 | MIRT026315 | Microarray | Functional MTI (Weak) | 19074876 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
