HCSGD entry for ARHGEF3
1. General information
| Official gene symbol | ARHGEF3 |
|---|---|
| Entrez ID | 50650 |
| Gene full name | Rho guanine nucleotide exchange factor (GEF) 3 |
| Other gene symbols | GEF3 STA3 XPLN |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0005089 | Rho guanyl-nucleotide exchange factor activity | IEA | molecular_function |
| GO:0005622 | Intracellular | IDA | cellular_component |
| GO:0005829 | Cytosol | TAS | cellular_component |
| GO:0007264 | Small GTPase mediated signal transduction | TAS | biological_process |
| GO:0007266 | Rho protein signal transduction | TAS | biological_process |
| GO:0032318 | Regulation of Ras GTPase activity | TAS | biological_process |
| GO:0032319 | Regulation of Rho GTPase activity | TAS | biological_process |
| GO:0035556 | Intracellular signal transduction | IEA | biological_process |
| GO:0043065 | Positive regulation of apoptotic process | TAS | biological_process |
| GO:0043087 | Regulation of GTPase activity | TAS | biological_process |
| GO:0048011 | Neurotrophin TRK receptor signaling pathway | TAS | biological_process |
| GO:0051056 | Regulation of small GTPase mediated signal transduction | TAS | biological_process |
| GO:0097190 | Apoptotic signaling pathway | TAS | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.0007545192 | 0.6621978040 | 0.0773316602 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 1.0259040002 |
| GSE13712_SHEAR | Down | -0.7139970960 |
| GSE13712_STATIC | Down | -0.2339975622 |
| GSE19018 | Down | -1.4059683360 |
| GSE19899_A1 | Up | 2.0773649483 |
| GSE19899_A2 | Up | 1.4105396054 |
| PubMed_21979375_A1 | Up | 2.5877207418 |
| PubMed_21979375_A2 | Up | 3.8442144413 |
| GSE35957 | Up | 0.7025195088 |
| GSE36640 | Up | 1.4577274067 |
| GSE54402 | Up | 0.1894106796 |
| GSE9593 | Up | 0.0149670061 |
| GSE43922 | Up | 1.7006299389 |
| GSE24585 | Up | 0.2312130870 |
| GSE37065 | Up | 0.1835076948 |
| GSE28863_A1 | Up | 0.2977686362 |
| GSE28863_A2 | Up | 0.3787444829 |
| GSE28863_A3 | Up | 0.1467380418 |
| GSE28863_A4 | Down | -0.1914937581 |
| GSE48662 | Down | -0.3175122422 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-138-5p | MIMAT0000430 | MIRT000493 | qRT-PCR//Luciferase reporter assay//Western blot | Non-Functional MTI | 20232393 |
| hsa-miR-373-3p | MIMAT0000726 | MIRT002512 | Microarray//Microarray;Other | Functional MTI (Weak) | 15685193 |
| hsa-miR-335-5p | MIMAT0000765 | MIRT016803 | Microarray | Functional MTI (Weak) | 18185580 |
| hsa-miR-769-5p | MIMAT0003886 | MIRT039147 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
- mirRecord
MicroRNA name | mirBase ID | Target site number | MiRNA mature ID | Test method inter | MiRNA regulation site | Reporter target site | Pubmed ID |
|---|---|---|---|---|---|---|---|
| hsa-miR-373-3p | MIMAT0000726 | NA | hsa-miR-373 | 15685193 |
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6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
