HCSGD entry for PAK1

1. General information

Official gene symbolPAK1
Entrez ID5058
Gene full namep21 protein (Cdc42/Rac)-activated kinase 1
Other gene symbolsPAKalpha
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000165MAPK cascadeIDAbiological_process
GO:0000278Mitotic cell cycleIBAbiological_process
GO:0001666Response to hypoxiaIEAbiological_process
GO:0001726RuffleIDAcellular_component
GO:0001934Positive regulation of protein phosphorylationIMPbiological_process
GO:0004672Protein kinase activityIDAmolecular_function
GO:0004674Protein serine/threonine kinase activityIDA IEA TASmolecular_function
GO:0004702Receptor signaling protein serine/threonine kinase activityIBAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005518Collagen bindingIPImolecular_function
GO:0005524ATP bindingIEAmolecular_function
GO:0005737CytoplasmIDAcellular_component
GO:0005794Golgi apparatusIDAcellular_component
GO:0005829CytosolIEA TAScellular_component
GO:0005886Plasma membraneIDA IEAcellular_component
GO:0005911Cell-cell junctionIDAcellular_component
GO:0005925Focal adhesionIEAcellular_component
GO:0006468Protein phosphorylationIDAbiological_process
GO:0006887ExocytosisIEAbiological_process
GO:0006915Apoptotic processIEAbiological_process
GO:0007409AxonogenesisIBAbiological_process
GO:0007411Axon guidanceTASbiological_process
GO:0007528Neuromuscular junction developmentIEAbiological_process
GO:0014704Intercalated discIEA ISScellular_component
GO:0016358Dendrite developmentIEAbiological_process
GO:0019901Protein kinase bindingIEAmolecular_function
GO:0023014Signal transduction by phosphorylationIBAbiological_process
GO:0030018Z discIEA ISScellular_component
GO:0030424AxonIEA ISScellular_component
GO:0030425DendriteIEA ISScellular_component
GO:0030426Growth coneIEAcellular_component
GO:0031295T cell costimulationTASbiological_process
GO:0031532Actin cytoskeleton reorganizationIDA IMPbiological_process
GO:0031941Filamentous actinNAScellular_component
GO:0031965Nuclear membraneIEA ISScellular_component
GO:0032869Cellular response to insulin stimulusIEAbiological_process
GO:0032956Regulation of actin cytoskeleton organizationIEAbiological_process
GO:0033138Positive regulation of peptidyl-serine phosphorylationIDAbiological_process
GO:0033148Positive regulation of intracellular estrogen receptor signaling pathwayIDAbiological_process
GO:0035556Intracellular signal transductionIBAbiological_process
GO:0038095Fc-epsilon receptor signaling pathwayTASbiological_process
GO:0038096Fc-gamma receptor signaling pathway involved in phagocytosisTASbiological_process
GO:0042060Wound healingIMPbiological_process
GO:0043113Receptor clusteringIEAbiological_process
GO:0043234Protein complexIDAcellular_component
GO:0043507Positive regulation of JUN kinase activityIMPbiological_process
GO:0045087Innate immune responseTASbiological_process
GO:0046777Protein autophosphorylationIDA IEAbiological_process
GO:0048754Branching morphogenesis of an epithelial tubeIMPbiological_process
GO:0048812Neuron projection morphogenesisIEA ISSbiological_process
GO:0050852T cell receptor signaling pathwayTASbiological_process
GO:0051496Positive regulation of stress fiber assemblyIMPbiological_process
GO:0060244Negative regulation of cell proliferation involved in contact inhibitionIMPbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.31224455000.17658696480.99999024730.8133223194

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.0148306858
GSE13712_SHEARUp0.3737638889
GSE13712_STATICUp0.7824593763
GSE19018Up0.5620996591
GSE19899_A1Down-0.1812519844
GSE19899_A2Down-0.5315995162
PubMed_21979375_A1Down-0.6821718031
PubMed_21979375_A2Down-0.6399962635
GSE35957Down-0.0127515572
GSE36640Down-0.3532817054
GSE54402Down-0.0311385744
GSE9593Up0.2066148778
GSE43922Down-0.2985838350
GSE24585Up0.0559911478
GSE37065Down-0.1559672439
GSE28863_A1Up0.1332392166
GSE28863_A2Up0.5983164937
GSE28863_A3Down-0.2326647459
GSE28863_A4Up0.1544396905
GSE48662Down-0.4849942902

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-7-5pMIMAT0000252MIRT000668Luciferase reporter assay//Western blotFunctional MTI18922890
hsa-miR-7-5pMIMAT0000252MIRT000668MicroarrayFunctional MTI (Weak)19073608
hsa-miR-377-3pMIMAT0000730MIRT000991Luciferase reporter assay//Western blotFunctional MTI18716028
hsa-miR-122-5pMIMAT0000421MIRT023312MicroarrayFunctional MTI (Weak)17612493
hsa-miR-26b-5pMIMAT0000083MIRT029738MicroarrayFunctional MTI (Weak)19088304
hsa-miR-423-5pMIMAT0004748MIRT038058CLASHFunctional MTI (Weak)23622248
hsa-miR-320aMIMAT0000510MIRT044750CLASHFunctional MTI (Weak)23622248
hsa-let-7b-5pMIMAT0000063MIRT051883CLASHFunctional MTI (Weak)23622248
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    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.