HCSGD entry for SERPINB2
1. General information
| Official gene symbol | SERPINB2 |
|---|---|
| Entrez ID | 5055 |
| Gene full name | serpin peptidase inhibitor, clade B (ovalbumin), member 2 |
| Other gene symbols | HsT1201 PAI PAI-2 PAI2 PLANH2 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0004867 | Serine-type endopeptidase inhibitor activity | IBA IEA | molecular_function |
| GO:0005576 | Extracellular region | TAS | cellular_component |
| GO:0005615 | Extracellular space | IEA | cellular_component |
| GO:0005737 | Cytoplasm | IEA | cellular_component |
| GO:0005886 | Plasma membrane | TAS | cellular_component |
| GO:0007596 | Blood coagulation | TAS | biological_process |
| GO:0010951 | Negative regulation of endopeptidase activity | IBA | biological_process |
| GO:0030162 | Regulation of proteolysis | IBA | biological_process |
| GO:0042060 | Wound healing | IEA | biological_process |
| GO:0042730 | Fibrinolysis | TAS | biological_process |
| GO:0043066 | Negative regulation of apoptotic process | IEA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.0000100604 | 0.0415712245 | 0.0115777778 | 0.3836592567 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 2.5474752787 |
| GSE13712_SHEAR | Down | -1.2150118792 |
| GSE13712_STATIC | Down | -3.0957445243 |
| GSE19018 | Down | -3.1041216917 |
| GSE19899_A1 | Up | 5.9334927271 |
| GSE19899_A2 | Up | 5.3306108232 |
| PubMed_21979375_A1 | Up | 3.1870214822 |
| PubMed_21979375_A2 | Up | 3.1602154632 |
| GSE35957 | Up | 3.7377468285 |
| GSE36640 | Up | 6.5325311393 |
| GSE54402 | Up | 2.5759518450 |
| GSE9593 | Up | 1.1293435956 |
| GSE43922 | - | - |
| GSE24585 | - | - |
| GSE37065 | - | - |
| GSE28863_A1 | Down | -0.8953097761 |
| GSE28863_A2 | Up | 1.5674614411 |
| GSE28863_A3 | Up | 0.8504972578 |
| GSE28863_A4 | Down | -0.4337811266 |
| GSE48662 | Down | -0.2031771394 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Name | Drug | Accession number |
|---|---|---|
| Urokinase | DB00013 | BTD00030 | BIOD00030 |
| Tenecteplase | DB00031 | BTD00019 | BIOD00019 |
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-124-3p | MIMAT0000422 | MIRT023021 | Microarray | Functional MTI (Weak) | 18668037 |
| hsa-miR-26b-5p | MIMAT0000083 | MIRT030054 | Microarray | Functional MTI (Weak) | 19088304 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 3 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 17266044 | Array CGH revealed genomic changes resembling those of ovarian carcinomas, such as amplicons at 3q and 20q, and deletions at 4q and 18, associated with underexpressed annexin A10, N-cadherin, desmocollin 3 and PAI-2, which have been reported as tumor suppressors |
| 12370286 | Overexpression of APA-1 did not cause cell cycle arrest; but, it induced transcription of the extracellular matrix-remodeling genes MMP1 and PAI2, which are associated with fibroblast senescence |
| 12370286 | MMP1 and PAI2 transcript levels also increased in telomerase-immortalized fibroblasts that had high levels of APA-1, demonstrating that the matrix-remodeling phenotype of senescent fibroblasts was not induced by telomere attrition alone |
| 8706787 | Young and senescent cells were compared in quiescent and activated growth conditions for the secretion of tissue-type plasminogen activator (t-PA), urokinase-type plasminogen activator (u-PA), plasminogen activator inhibitor-1 (PAI-1) and plasminogen activator inhibitor-2 (PAI-2) |
| 8706787 | In contrast, both t-PA and PAI-2 were markedly overexpressed in senescent skin lung cells under all growth conditions |
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