HCSGD entry for PAH
1. General information
| Official gene symbol | PAH |
|---|---|
| Entrez ID | 5053 |
| Gene full name | phenylalanine hydroxylase |
| Other gene symbols | PH PKU PKU1 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0004505 | Phenylalanine 4-monooxygenase activity | EXP IEA | molecular_function |
| GO:0005506 | Iron ion binding | IEA | molecular_function |
| GO:0005829 | Cytosol | TAS | cellular_component |
| GO:0006559 | L-phenylalanine catabolic process | IEA TAS | biological_process |
| GO:0008652 | Cellular amino acid biosynthetic process | TAS | biological_process |
| GO:0009072 | Aromatic amino acid family metabolic process | IEA | biological_process |
| GO:0016597 | Amino acid binding | IEA | molecular_function |
| GO:0034641 | Cellular nitrogen compound metabolic process | TAS | biological_process |
| GO:0042136 | Neurotransmitter biosynthetic process | NAS | biological_process |
| GO:0042423 | Catecholamine biosynthetic process | NAS | biological_process |
| GO:0044281 | Small molecule metabolic process | TAS | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.6622650089 | 0.9699518521 | 0.9999902473 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | - | - |
| GSE13712_SHEAR | - | - |
| GSE13712_STATIC | - | - |
| GSE19018 | - | - |
| GSE19899_A1 | - | - |
| GSE19899_A2 | - | - |
| PubMed_21979375_A1 | - | - |
| PubMed_21979375_A2 | - | - |
| GSE35957 | - | - |
| GSE36640 | - | - |
| GSE54402 | - | - |
| GSE9593 | - | - |
| GSE43922 | - | - |
| GSE24585 | - | - |
| GSE37065 | - | - |
| GSE28863_A1 | - | - |
| GSE28863_A2 | - | - |
| GSE28863_A3 | - | - |
| GSE28863_A4 | - | - |
| GSE48662 | Up | 0.0431153319 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Name | Drug | Accession number |
|---|---|---|
| L-Phenylalanine | DB00120 | NUTR00044 |
| Quinonoid 7,8-Tetrahydrobiopterin | DB02562 | EXPT01676 |
| Beta(2-Thienyl)Alanine | DB03673 | EXPT03063 |
| 7,8-Dihydrobiopterin | DB04400 | EXPT01697 | DB03271 | EXPT01698 |
| Norleucine | DB04419 | EXPT02355 |
| Droxidopa | DB06262 | - |
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-335-5p | MIMAT0000765 | MIRT018158 | Microarray | Functional MTI (Weak) | 18185580 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 20629482 | Old passage cells of both the H9 and PKU1 lines were characterized by higher mitochondrial membrane potential, larger mitochondrial morphology, and higher reactive oxygen species content than their younger counterparts |
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