HCSGD entry for P4HA1
1. General information
| Official gene symbol | P4HA1 |
|---|---|
| Entrez ID | 5033 |
| Gene full name | prolyl 4-hydroxylase, alpha polypeptide I |
| Other gene symbols | P4HA |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0004656 | Procollagen-proline 4-dioxygenase activity | IEA | molecular_function |
| GO:0005506 | Iron ion binding | IEA | molecular_function |
| GO:0005739 | Mitochondrion | IDA | cellular_component |
| GO:0005783 | Endoplasmic reticulum | IDA | cellular_component |
| GO:0005788 | Endoplasmic reticulum lumen | IEA | cellular_component |
| GO:0016702 | Oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen | IEA | molecular_function |
| GO:0018401 | Peptidyl-proline hydroxylation to 4-hydroxy-L-proline | IEA | biological_process |
| GO:0030199 | Collagen fibril organization | IEA | biological_process |
| GO:0031418 | L-ascorbic acid binding | IEA | molecular_function |
| GO:0043231 | Intracellular membrane-bounded organelle | IDA | cellular_component |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.2320678850 | 0.3316029140 | 0.9156997153 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.2436886646 |
| GSE13712_SHEAR | Up | 0.1289823123 |
| GSE13712_STATIC | Up | 0.0989373461 |
| GSE19018 | Up | 0.6942887958 |
| GSE19899_A1 | Up | 0.0249203773 |
| GSE19899_A2 | Down | -0.1296847923 |
| PubMed_21979375_A1 | Down | -0.0719994252 |
| PubMed_21979375_A2 | Down | -0.0281492596 |
| GSE35957 | Down | -0.4452571859 |
| GSE36640 | Down | -0.2661039759 |
| GSE54402 | Down | -0.0598161283 |
| GSE9593 | Up | 0.1811527162 |
| GSE43922 | Up | 0.2974369278 |
| GSE24585 | Up | 0.4799405976 |
| GSE37065 | Down | -0.2415329225 |
| GSE28863_A1 | Up | 0.0698288216 |
| GSE28863_A2 | Up | 0.2173468594 |
| GSE28863_A3 | Down | -0.5956698749 |
| GSE28863_A4 | Down | -0.0429896057 |
| GSE48662 | Up | 0.2813040632 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Name | Drug | Accession number |
|---|---|---|
| Vitamin C | DB00126 | NUTR00001 | APRD00084 | EXPT00568 | DB09541 |
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-122-5p | MIMAT0000421 | MIRT007082 | Luciferase reporter assay | Functional MTI | 23178710 |
| hsa-miR-335-5p | MIMAT0000765 | MIRT018997 | Microarray | Functional MTI (Weak) | 18185580 |
| hsa-miR-941 | MIMAT0004984 | MIRT036574 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-877-3p | MIMAT0004950 | MIRT036866 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-320a | MIMAT0000510 | MIRT044845 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
