HCSGD entry for P2RX7

1. General information

Official gene symbolP2RX7
Entrez ID5027
Gene full namepurinergic receptor P2X, ligand-gated ion channel, 7
Other gene symbolsP2X7
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

color bar
This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000187Activation of MAPK activityIEAbiological_process
GO:0000287Magnesium ion bindingIEAmolecular_function
GO:0000902Cell morphogenesisIEAbiological_process
GO:0001530Lipopolysaccharide bindingISSmolecular_function
GO:0001614Purinergic nucleotide receptor activityIDA IEAmolecular_function
GO:0001845Phagolysosome assemblyIEAbiological_process
GO:0001916Positive regulation of T cell mediated cytotoxicityIEAbiological_process
GO:0002028Regulation of sodium ion transportISSbiological_process
GO:0004931Extracellular ATP-gated cation channel activityIDAmolecular_function
GO:0005102Receptor bindingISSmolecular_function
GO:0005216Ion channel activityIEAmolecular_function
GO:0005507Copper ion bindingIEAmolecular_function
GO:0005524ATP bindingIC IEAmolecular_function
GO:0005639Integral component of nuclear inner membraneIEAcellular_component
GO:0005737CytoplasmISScellular_component
GO:0005886Plasma membraneISS TAScellular_component
GO:0005887Integral component of plasma membraneICcellular_component
GO:0005911Cell-cell junctionIEAcellular_component
GO:0006468Protein phosphorylationIEAbiological_process
GO:0006509Membrane protein ectodomain proteolysisIEAbiological_process
GO:0006649Phospholipid transfer to membraneIEAbiological_process
GO:0006884Cell volume homeostasisIEAbiological_process
GO:0006900Membrane buddingIEAbiological_process
GO:0006954Inflammatory responseIEAbiological_process
GO:0007005Mitochondrion organizationIEAbiological_process
GO:0007009Plasma membrane organizationIEAbiological_process
GO:0007166Cell surface receptor signaling pathwayISSbiological_process
GO:0008270Zinc ion bindingIEAmolecular_function
GO:0009612Response to mechanical stimulusIEAbiological_process
GO:0009897External side of plasma membraneIEAcellular_component
GO:0010043Response to zinc ionIEAbiological_process
GO:0010524Positive regulation of calcium ion transport into cytosolIDAbiological_process
GO:0014049Positive regulation of glutamate secretionIEAbiological_process
GO:0014054Positive regulation of gamma-aminobutyric acid secretionIEAbiological_process
GO:0016020MembraneIDA IEAcellular_component
GO:0016079Synaptic vesicle exocytosisIEAbiological_process
GO:0016485Protein processingIEAbiological_process
GO:0019228Neuronal action potentialIEAbiological_process
GO:0019233Sensory perception of painISSbiological_process
GO:0019835CytolysisIEAbiological_process
GO:0030501Positive regulation of bone mineralizationISSbiological_process
GO:0031594Neuromuscular junctionIEAcellular_component
GO:0031668Cellular response to extracellular stimulusIEAbiological_process
GO:0032059BlebISScellular_component
GO:0032060Bleb assemblyISSbiological_process
GO:0032308Positive regulation of prostaglandin secretionIEAbiological_process
GO:0032496Response to lipopolysaccharideIEAbiological_process
GO:0032755Positive regulation of interleukin-6 productionIEAbiological_process
GO:0032963Collagen metabolic processIEAbiological_process
GO:0033198Response to ATPIDAbiological_process
GO:0034220Ion transmembrane transportIDAbiological_process
GO:0034405Response to fluid shear stressIEAbiological_process
GO:0035872Nucleotide-binding domain, leucine rich repeat containing receptor signaling pathwayTASbiological_process
GO:0042098T cell proliferationIEAbiological_process
GO:0042493Response to drugIEAbiological_process
GO:0042803Protein homodimerization activityNASmolecular_function
GO:0043025Neuronal cell bodyIEAcellular_component
GO:0043029T cell homeostasisIEAbiological_process
GO:0043132NAD transportIEAbiological_process
GO:0043195Terminal boutonIEAcellular_component
GO:0043234Protein complexIEAcellular_component
GO:0043409Negative regulation of MAPK cascadeISSbiological_process
GO:0044254Multicellular organismal protein catabolic processIEAbiological_process
GO:0045087Innate immune responseTASbiological_process
GO:0045121Membrane raftIEAcellular_component
GO:0045332Phospholipid translocationIEAbiological_process
GO:0045779Negative regulation of bone resorptionISSbiological_process
GO:0045919Positive regulation of cytolysisISSbiological_process
GO:0046513Ceramide biosynthetic processIEAbiological_process
GO:0046931Pore complex assemblyIDAbiological_process
GO:0048705Skeletal system morphogenesisIEAbiological_process
GO:0048873Homeostasis of number of cells within a tissueIEAbiological_process
GO:0050717Positive regulation of interleukin-1 alpha secretionIEAbiological_process
GO:0050718Positive regulation of interleukin-1 beta secretionIDAbiological_process
GO:0050830Defense response to Gram-positive bacteriumIEAbiological_process
GO:0051209Release of sequestered calcium ion into cytosolIEAbiological_process
GO:0051259Protein oligomerizationIEAbiological_process
GO:0051495Positive regulation of cytoskeleton organizationISSbiological_process
GO:0051592Response to calcium ionIEAbiological_process
GO:0051602Response to electrical stimulusIEAbiological_process
GO:0051709Regulation of killing of cells of other organismNASbiological_process
GO:0051899Membrane depolarizationIDAbiological_process
GO:0051901Positive regulation of mitochondrial depolarizationIEAbiological_process
GO:0055085Transmembrane transportIDAbiological_process
GO:0070230Positive regulation of lymphocyte apoptotic processIEAbiological_process
GO:0072593Reactive oxygen species metabolic processIEAbiological_process
GO:0097110Scaffold protein bindingIEAmolecular_function
GO:0097190Apoptotic signaling pathwayISSbiological_process
Entries Per Page
Displaying Page of

4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.27248895180.15857073440.96963108020.7695260693

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.0275469851
GSE13712_SHEARDown-0.3844928034
GSE13712_STATICDown-0.4944738572
GSE19018Down-0.1157575054
GSE19899_A1Up0.0381955835
GSE19899_A2Down-0.8075450399
PubMed_21979375_A1Down-0.2901494640
PubMed_21979375_A2Down-0.2952151485
GSE35957Down-0.1038795509
GSE36640Down-0.2089715333
GSE54402Down-0.4925766476
GSE9593Up0.4704773531
GSE43922Down-0.0470577261
GSE24585Up0.0459933666
GSE37065Up0.5133015124
GSE28863_A1Up0.0828332788
GSE28863_A2Up2.0936561870
GSE28863_A3Up0.0814584117
GSE28863_A4Down-0.0012900709
GSE48662Up0.1762819951

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-186-5pMIMAT0000456MIRT004356qRT-PCR//Luciferase reporter assayFunctional MTI18682393
hsa-miR-150-5pMIMAT0000451MIRT004357qRT-PCR//Luciferase reporter assayFunctional MTI18682393
Entries Per Page
Displaying Page of
    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

23964074Lysosomal alkalinization, lipid oxidation, and reduced phagosome clearance triggered by activation of the P2X7 receptor
23964074Here, we demonstrate that stimulation of the P2X7 receptor (P2X7R) for ATP alkalinizes lysosomes in cultured human retinal pigmented epithelial (RPE) cells and impairs lysosomal function
Entries Per Page
Displaying Page of