HCSGD entry for ALDH7A1


1. General information

Official gene symbolALDH7A1
Entrez ID501
Gene full namealdehyde dehydrogenase 7 family, member A1
Other gene symbolsATQ1 EPD PDE
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

color bar
This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0004029Aldehyde dehydrogenase (NAD) activityISSmolecular_function
GO:0004043L-aminoadipate-semialdehyde dehydrogenase activityEXPmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005634NucleusIEAcellular_component
GO:0005737CytoplasmIDAcellular_component
GO:0005739MitochondrionIDAcellular_component
GO:0005759Mitochondrial matrixTAScellular_component
GO:0005829CytosolIEAcellular_component
GO:0006081Cellular aldehyde metabolic processISSbiological_process
GO:0006554Lysine catabolic processTASbiological_process
GO:0007605Sensory perception of soundTASbiological_process
GO:0008802Betaine-aldehyde dehydrogenase activityIEAmolecular_function
GO:0016491Oxidoreductase activityIEAmolecular_function
GO:0016620Oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptorIEAmolecular_function
GO:0019285Glycine betaine biosynthetic process from cholineIEAbiological_process
GO:0034641Cellular nitrogen compound metabolic processTASbiological_process
GO:0044281Small molecule metabolic processTASbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.98848675960.00174574290.99999024730.0800517422

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.5208080856
GSE13712_SHEARDown-0.5882955580
GSE13712_STATICDown-0.6121948132
GSE19018Up0.1681996064
GSE19899_A1Down-0.7752633842
GSE19899_A2Down-1.1811776468
PubMed_21979375_A1Down-2.0852212641
PubMed_21979375_A2Down-1.4459399819
GSE35957Down-0.0654342512
GSE36640Down-1.1109364480
GSE54402Down-0.7812116276
GSE9593Down-0.0339145429
GSE43922Down-0.7914317285
GSE24585Up0.4198189957
GSE37065Down-0.5620885035
GSE28863_A1Down-0.0049659507
GSE28863_A2Down-0.0857737293
GSE28863_A3Down-0.3995633422
GSE28863_A4Down-0.0569602672
GSE48662Down-0.1023336790

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

NADHDB00157 NUTR00041 | DB01907 | EXPT02287 | DB03527

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-193b-3pMIMAT0002819MIRT041487CLASHFunctional MTI (Weak)23622248
hsa-let-7f-5pMIMAT0000067MIRT051376CLASHFunctional MTI (Weak)23622248
hsa-let-7b-5pMIMAT0000063MIRT051932CLASHFunctional MTI (Weak)23622248
hsa-let-7a-5pMIMAT0000062MIRT052595CLASHFunctional MTI (Weak)23622248
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    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 3 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

26464516Inhibition of phosphodiesterase (PDE) 1 and 5 normalized SNP-relaxing effects in Ercc1(d/-) to wild-type (WT) levels
23274627To assess the integrity of the peritoneal membrane, we characterized the functionality of the cellular components derived from peritoneal dialysis effluent (PDE)
23274627About 3 % of all cells collected from the PDE attached to the plastic dish, and 97
23274627We conclude that functional characterization of cellular components in PDE reflects how well the peritoneum is preserved
202816We also observed an increase in Vmax of uridine transport, and a decrease in the Km of cyclic AMP phosphodiesterase (PDE) as quiescent, passage 18-25, HELF were stimulated to divide with fresh serum
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