HCSGD entry for ALDH7A1
1. General information
Official gene symbol | ALDH7A1 |
---|---|
Entrez ID | 501 |
Gene full name | aldehyde dehydrogenase 7 family, member A1 |
Other gene symbols | ATQ1 EPD PDE |
Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network

This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
---|---|---|---|
GO:0004029 | Aldehyde dehydrogenase (NAD) activity | ISS | molecular_function |
GO:0004043 | L-aminoadipate-semialdehyde dehydrogenase activity | EXP | molecular_function |
GO:0005515 | Protein binding | IPI | molecular_function |
GO:0005634 | Nucleus | IEA | cellular_component |
GO:0005737 | Cytoplasm | IDA | cellular_component |
GO:0005739 | Mitochondrion | IDA | cellular_component |
GO:0005759 | Mitochondrial matrix | TAS | cellular_component |
GO:0005829 | Cytosol | IEA | cellular_component |
GO:0006081 | Cellular aldehyde metabolic process | ISS | biological_process |
GO:0006554 | Lysine catabolic process | TAS | biological_process |
GO:0007605 | Sensory perception of sound | TAS | biological_process |
GO:0008802 | Betaine-aldehyde dehydrogenase activity | IEA | molecular_function |
GO:0016491 | Oxidoreductase activity | IEA | molecular_function |
GO:0016620 | Oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor | IEA | molecular_function |
GO:0019285 | Glycine betaine biosynthetic process from choline | IEA | biological_process |
GO:0034641 | Cellular nitrogen compound metabolic process | TAS | biological_process |
GO:0044281 | Small molecule metabolic process | TAS | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
p-value up | p-value down | FDR up | FDR down |
---|---|---|---|
0.9884867596 | 0.0017457429 | 0.9999902473 | 0.0800517422 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
Data source | Up or down | Log fold change |
---|---|---|
GSE11954 | Down | -0.5208080856 |
GSE13712_SHEAR | Down | -0.5882955580 |
GSE13712_STATIC | Down | -0.6121948132 |
GSE19018 | Up | 0.1681996064 |
GSE19899_A1 | Down | -0.7752633842 |
GSE19899_A2 | Down | -1.1811776468 |
PubMed_21979375_A1 | Down | -2.0852212641 |
PubMed_21979375_A2 | Down | -1.4459399819 |
GSE35957 | Down | -0.0654342512 |
GSE36640 | Down | -1.1109364480 |
GSE54402 | Down | -0.7812116276 |
GSE9593 | Down | -0.0339145429 |
GSE43922 | Down | -0.7914317285 |
GSE24585 | Up | 0.4198189957 |
GSE37065 | Down | -0.5620885035 |
GSE28863_A1 | Down | -0.0049659507 |
GSE28863_A2 | Down | -0.0857737293 |
GSE28863_A3 | Down | -0.3995633422 |
GSE28863_A4 | Down | -0.0569602672 |
GSE48662 | Down | -0.1023336790 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Name | Drug | Accession number |
---|---|---|
NADH | DB00157 | NUTR00041 | DB01907 | EXPT02287 | DB03527 |
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
---|---|---|---|---|---|
hsa-miR-193b-3p | MIMAT0002819 | MIRT041487 | CLASH | Functional MTI (Weak) | 23622248 |
hsa-let-7f-5p | MIMAT0000067 | MIRT051376 | CLASH | Functional MTI (Weak) | 23622248 |
hsa-let-7b-5p | MIMAT0000063 | MIRT051932 | CLASH | Functional MTI (Weak) | 23622248 |
hsa-let-7a-5p | MIMAT0000062 | MIRT052595 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 3 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
---|---|
26464516 | Inhibition of phosphodiesterase (PDE) 1 and 5 normalized SNP-relaxing effects in Ercc1(d/-) to wild-type (WT) levels |
23274627 | To assess the integrity of the peritoneal membrane, we characterized the functionality of the cellular components derived from peritoneal dialysis effluent (PDE) |
23274627 | About 3 % of all cells collected from the PDE attached to the plastic dish, and 97 |
23274627 | We conclude that functional characterization of cellular components in PDE reflects how well the peritoneum is preserved |
202816 | We also observed an increase in Vmax of uridine transport, and a decrease in the Km of cyclic AMP phosphodiesterase (PDE) as quiescent, passage 18-25, HELF were stimulated to divide with fresh serum |
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