HCSGD entry for OTC

1. General information

Official gene symbolOTC
Entrez ID5009
Gene full nameornithine carbamoyltransferase
Other gene symbolsOCTD
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000050Urea cycleIEA TASbiological_process
GO:0001889Liver developmentIEAbiological_process
GO:0004585Ornithine carbamoyltransferase activityEXPmolecular_function
GO:0005543Phospholipid bindingIEAmolecular_function
GO:0005739MitochondrionIDAcellular_component
GO:0005743Mitochondrial inner membraneIEAcellular_component
GO:0005759Mitochondrial matrixNAS TAScellular_component
GO:0006526Arginine biosynthetic processIEAbiological_process
GO:0007494Midgut developmentIEAbiological_process
GO:0010043Response to zinc ionIEAbiological_process
GO:0016597Amino acid bindingIEAmolecular_function
GO:0019240Citrulline biosynthetic processIEAbiological_process
GO:0032868Response to insulinIEAbiological_process
GO:0034641Cellular nitrogen compound metabolic processTASbiological_process
GO:0042301Phosphate ion bindingIEAmolecular_function
GO:0042493Response to drugIEAbiological_process
GO:0044281Small molecule metabolic processTASbiological_process
GO:0055081Anion homeostasisIEAbiological_process
GO:0070207Protein homotrimerizationIEAbiological_process
GO:0070781Response to biotinIEAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.56528292240.89724133200.99999024731.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.1218360289
GSE13712_SHEARDown-0.0043694672
GSE13712_STATICDown-0.1740619961
GSE19018Up0.1984271853
GSE19899_A1Up0.0513845398
GSE19899_A2Up0.0301365180
PubMed_21979375_A1Down-0.0341106536
PubMed_21979375_A2Up0.0435342074
GSE35957Up0.1457963923
GSE36640Down-0.0212474251
GSE54402Up0.0026552561
GSE9593Up0.3932864739
GSE43922Up0.0191703173
GSE24585Up0.1481216072
GSE37065Up0.0274508244
GSE28863_A1Up0.1376972273
GSE28863_A2Up0.0125774041
GSE28863_A3Up0.1201015313
GSE28863_A4Up0.0334261662
GSE48662Down-0.0155263317

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

L-OrnithineDB00129 NUTR00043
N-(Phosphonoacetyl)-L-OrnithineDB02011 EXPT02497
2-Amino-Pentanoic AcidDB03519 EXPT00144
NorvalineDB04185 EXPT02397

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-26b-5pMIMAT0000083MIRT028822MicroarrayFunctional MTI (Weak)19088304
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    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.