HCSGD entry for OSM
1. General information
| Official gene symbol | OSM |
|---|---|
| Entrez ID | 5008 |
| Gene full name | oncostatin M |
| Other gene symbols | |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0002675 | Positive regulation of acute inflammatory response | IC | biological_process |
| GO:0005125 | Cytokine activity | IDA IEA | molecular_function |
| GO:0005147 | Oncostatin-M receptor binding | IPI | molecular_function |
| GO:0005576 | Extracellular region | IEA | cellular_component |
| GO:0005615 | Extracellular space | IEA | cellular_component |
| GO:0005900 | Oncostatin-M receptor complex | IDA | cellular_component |
| GO:0006955 | Immune response | IEA | biological_process |
| GO:0007275 | Multicellular organismal development | TAS | biological_process |
| GO:0007422 | Peripheral nervous system development | IEA | biological_process |
| GO:0008083 | Growth factor activity | IDA | molecular_function |
| GO:0008283 | Cell proliferation | TAS | biological_process |
| GO:0008284 | Positive regulation of cell proliferation | IDA | biological_process |
| GO:0008285 | Negative regulation of cell proliferation | TAS | biological_process |
| GO:0009408 | Response to heat | IEA | biological_process |
| GO:0033138 | Positive regulation of peptidyl-serine phosphorylation | IDA | biological_process |
| GO:0040008 | Regulation of growth | IEA | biological_process |
| GO:0042503 | Tyrosine phosphorylation of Stat3 protein | IEA | biological_process |
| GO:0042506 | Tyrosine phosphorylation of Stat5 protein | IEA | biological_process |
| GO:0042508 | Tyrosine phosphorylation of Stat1 protein | IEA | biological_process |
| GO:0043410 | Positive regulation of MAPK cascade | IDA | biological_process |
| GO:0045835 | Negative regulation of meiosis | IEA | biological_process |
| GO:0045944 | Positive regulation of transcription from RNA polymerase II promoter | IDA | biological_process |
| GO:0046888 | Negative regulation of hormone secretion | IDA | biological_process |
| GO:0048266 | Behavioral response to pain | IEA | biological_process |
| GO:0050731 | Positive regulation of peptidyl-tyrosine phosphorylation | IDA | biological_process |
| GO:0051781 | Positive regulation of cell division | IEA | biological_process |
| GO:2001235 | Positive regulation of apoptotic signaling pathway | IEA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.8961267391 | 0.2952098135 | 0.9999902473 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.0287053141 |
| GSE13712_SHEAR | Down | -0.1412795359 |
| GSE13712_STATIC | Up | 0.0239674088 |
| GSE19018 | Up | 0.0257323048 |
| GSE19899_A1 | Down | -0.0334242560 |
| GSE19899_A2 | Up | 0.3245658003 |
| PubMed_21979375_A1 | Down | -0.0549751844 |
| PubMed_21979375_A2 | Down | -0.1336276063 |
| GSE35957 | Up | 0.1439996530 |
| GSE36640 | Up | 0.1644264391 |
| GSE54402 | Up | 0.0902752876 |
| GSE9593 | Down | -0.0151143431 |
| GSE43922 | Up | 0.0137334027 |
| GSE24585 | Down | -0.0413552563 |
| GSE37065 | Down | -0.0314314621 |
| GSE28863_A1 | Down | -0.4557780025 |
| GSE28863_A2 | Down | -0.4890104464 |
| GSE28863_A3 | Up | 0.2163797584 |
| GSE28863_A4 | Down | -0.2348651366 |
| GSE48662 | Up | 0.0248570809 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
No target information from mirTarBase
- mirTarBase
- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 27349249 | Effect of human papillomavirus 16 oncoproteins on oncostatin M upregulation in oral squamous cell carcinoma |
| 27349249 | Oncostatin M (OSM), an IL-6 family cytokine, acts to promote cell senescence and inhibit growth |
| 27349249 | Oncostatin M (OSM), an IL-6 family cytokine, acts to promote cell senescence and inhibit growth |
| 27349249 | The effect of HPV on OSM dysregulation has not been investigated |
| 27349249 | Immortalized human cervical keratinocytes expressing HPV16E6 (HCK1T, Tet-On system) were used to demonstrate the role of HPV16E6 in OSM expression |
| 27349249 | The results showed various intensities of OSM expression in OSCC |
| 27349249 | To explore the role of HPV oncoproteins on OSM expression, the expression of HPV16E6 in the HCK1T Tet-On condition was induced by doxycycline and HPV16E6 was found to significantly upregulate levels of OSM mRNA and protein, with concomitant upregulation of c-Myc |
| 27349249 | To explore the role of HPV oncoproteins on OSM expression, the expression of HPV16E6 in the HCK1T Tet-On condition was induced by doxycycline and HPV16E6 was found to significantly upregulate levels of OSM mRNA and protein, with concomitant upregulation of c-Myc |
| 27349249 | In addition, the levels of OSM mRNA and protein in E6/E7 transiently transfected oral cancer cells also gradually increased in a time-dependent manner and these transfected cells showed greater viability and higher migration rates and cell-cycle progression than controls |
| 27349249 | This result demonstrates that HPV16 oncoproteins upregulate OSM and play an important role to promote OSCC development |
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