HCSGD entry for ORC5
1. General information
| Official gene symbol | ORC5 |
|---|---|
| Entrez ID | 5001 |
| Gene full name | origin recognition complex, subunit 5 |
| Other gene symbols | ORC5L ORC5P ORC5T |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000082 | G1/S transition of mitotic cell cycle | TAS | biological_process |
| GO:0000166 | Nucleotide binding | TAS | molecular_function |
| GO:0000278 | Mitotic cell cycle | TAS | biological_process |
| GO:0000808 | Origin recognition complex | IDA IEA | cellular_component |
| GO:0003674 | Molecular_function | ND | molecular_function |
| GO:0003688 | DNA replication origin binding | TAS | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005524 | ATP binding | IEA | molecular_function |
| GO:0005634 | Nucleus | IDA IEA NAS | cellular_component |
| GO:0005654 | Nucleoplasm | TAS | cellular_component |
| GO:0005664 | Nuclear origin of replication recognition complex | IDA NAS | cellular_component |
| GO:0005737 | Cytoplasm | IDA | cellular_component |
| GO:0006260 | DNA replication | IEA NAS TAS | biological_process |
| GO:0006270 | DNA replication initiation | TAS | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.4620015083 | 0.2392194445 | 0.9999902473 | 0.9416023628 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.3758422902 |
| GSE13712_SHEAR | Up | 0.0196201551 |
| GSE13712_STATIC | Up | 0.1429156004 |
| GSE19018 | Down | -0.4207567430 |
| GSE19899_A1 | Up | 0.0551566151 |
| GSE19899_A2 | Up | 0.1631824730 |
| PubMed_21979375_A1 | Up | 0.6206687033 |
| PubMed_21979375_A2 | Down | -0.2936405856 |
| GSE35957 | Down | -0.3997467332 |
| GSE36640 | Down | -0.4025654240 |
| GSE54402 | Up | 0.3108653782 |
| GSE9593 | Down | -0.0357585877 |
| GSE43922 | Up | 0.1876682514 |
| GSE24585 | Down | -0.2193139130 |
| GSE37065 | Down | -0.0657922438 |
| GSE28863_A1 | Down | -0.0008025252 |
| GSE28863_A2 | Up | 0.3169041139 |
| GSE28863_A3 | Down | -0.6842544082 |
| GSE28863_A4 | Down | -0.0758465894 |
| GSE48662 | Down | -0.2761919296 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-186-5p | MIMAT0000456 | MIRT021090 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-100-5p | MIMAT0000098 | MIRT048551 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-99a-5p | MIMAT0000097 | MIRT048630 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-92a-3p | MIMAT0000092 | MIRT049358 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
