HCSGD entry for ORC4
1. General information
| Official gene symbol | ORC4 |
|---|---|
| Entrez ID | 5000 |
| Gene full name | origin recognition complex, subunit 4 |
| Other gene symbols | ORC4L ORC4P |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000082 | G1/S transition of mitotic cell cycle | TAS | biological_process |
| GO:0000166 | Nucleotide binding | IDA | molecular_function |
| GO:0000278 | Mitotic cell cycle | TAS | biological_process |
| GO:0000808 | Origin recognition complex | IDA | cellular_component |
| GO:0003688 | DNA replication origin binding | IMP | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005524 | ATP binding | IEA | molecular_function |
| GO:0005634 | Nucleus | IDA | cellular_component |
| GO:0005654 | Nucleoplasm | TAS | cellular_component |
| GO:0005664 | Nuclear origin of replication recognition complex | IDA | cellular_component |
| GO:0006260 | DNA replication | TAS | biological_process |
| GO:0006270 | DNA replication initiation | IMP | biological_process |
| GO:0017111 | Nucleoside-triphosphatase activity | IEA | molecular_function |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.5062612933 | 0.2069812393 | 0.9999902473 | 0.8818312075 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.3860402854 |
| GSE13712_SHEAR | Down | -0.1170137390 |
| GSE13712_STATIC | Up | 0.0277266060 |
| GSE19018 | Down | -0.1980647375 |
| GSE19899_A1 | Down | -0.1331595804 |
| GSE19899_A2 | Down | -0.0129235979 |
| PubMed_21979375_A1 | Up | 0.7973076772 |
| PubMed_21979375_A2 | Up | 0.0910492975 |
| GSE35957 | Up | 0.0221914027 |
| GSE36640 | Down | -0.5896087996 |
| GSE54402 | Down | -0.1650300057 |
| GSE9593 | Down | -0.0913702682 |
| GSE43922 | Down | -0.0433876475 |
| GSE24585 | Up | 0.0829772094 |
| GSE37065 | Up | 0.3815557591 |
| GSE28863_A1 | Up | 0.2665899251 |
| GSE28863_A2 | Up | 0.0399128361 |
| GSE28863_A3 | Down | -0.5738174373 |
| GSE28863_A4 | Down | -0.2578283830 |
| GSE48662 | Down | -0.2786842714 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-let-7b-5p | MIMAT0000063 | MIRT032381 | Proteomics | Functional MTI (Weak) | 18668040 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
