HCSGD entry for ORC1
1. General information
| Official gene symbol | ORC1 |
|---|---|
| Entrez ID | 4998 |
| Gene full name | origin recognition complex, subunit 1 |
| Other gene symbols | HSORC1 ORC1L PARC1 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000082 | G1/S transition of mitotic cell cycle | TAS | biological_process |
| GO:0000083 | Regulation of transcription involved in G1/S transition of mitotic cell cycle | TAS | biological_process |
| GO:0000278 | Mitotic cell cycle | TAS | biological_process |
| GO:0000808 | Origin recognition complex | IDA IEA | cellular_component |
| GO:0003677 | DNA binding | IEA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005524 | ATP binding | IEA | molecular_function |
| GO:0005634 | Nucleus | IDA IEA | cellular_component |
| GO:0005654 | Nucleoplasm | TAS | cellular_component |
| GO:0005664 | Nuclear origin of replication recognition complex | IDA | cellular_component |
| GO:0005730 | Nucleolus | IDA | cellular_component |
| GO:0005737 | Cytoplasm | IDA | cellular_component |
| GO:0005829 | Cytosol | TAS | cellular_component |
| GO:0005886 | Plasma membrane | IDA | cellular_component |
| GO:0006260 | DNA replication | IEA TAS | biological_process |
| GO:0006270 | DNA replication initiation | TAS | biological_process |
| GO:0017111 | Nucleoside-triphosphatase activity | IEA | molecular_function |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.9710500665 | 0.0046750085 | 0.9999902473 | 0.1384149606 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.0542995488 |
| GSE13712_SHEAR | Down | -0.0220447376 |
| GSE13712_STATIC | Down | -0.0619453454 |
| GSE19018 | Down | -0.0510392736 |
| GSE19899_A1 | Down | -0.3403649676 |
| GSE19899_A2 | Down | -1.7641421047 |
| PubMed_21979375_A1 | Down | -0.8099124505 |
| PubMed_21979375_A2 | Down | -1.5365517085 |
| GSE35957 | Down | -1.2994308970 |
| GSE36640 | Down | -1.2740310403 |
| GSE54402 | Down | -0.0635611892 |
| GSE9593 | Down | -1.0352288023 |
| GSE43922 | Down | -0.7729481799 |
| GSE24585 | Up | 0.0141184189 |
| GSE37065 | Down | -0.2126405377 |
| GSE28863_A1 | Up | 0.0545253218 |
| GSE28863_A2 | Up | 0.7346922214 |
| GSE28863_A3 | Down | -0.1411557864 |
| GSE28863_A4 | Down | -0.1627373795 |
| GSE48662 | Down | -0.4443214635 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-124-3p | MIMAT0000422 | MIRT023064 | Proteomics;Microarray | Non-Functional MTI (Weak) | 18668037 |
| hsa-miR-215-5p | MIMAT0000272 | MIRT024795 | Microarray | Functional MTI (Weak) | 19074876 |
| hsa-miR-192-5p | MIMAT0000222 | MIRT026765 | Microarray | Functional MTI (Weak) | 19074876 |
| hsa-miR-92b-3p | MIMAT0003218 | MIRT040662 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-320a | MIMAT0000510 | MIRT044432 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
