HCSGD entry for OAT
1. General information
| Official gene symbol | OAT |
|---|---|
| Entrez ID | 4942 |
| Gene full name | ornithine aminotransferase |
| Other gene symbols | GACR HOGA OATASE OKT |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0004587 | Ornithine-oxo-acid transaminase activity | EXP | molecular_function |
| GO:0005739 | Mitochondrion | TAS | cellular_component |
| GO:0005759 | Mitochondrial matrix | TAS | cellular_component |
| GO:0007601 | Visual perception | TAS | biological_process |
| GO:0008652 | Cellular amino acid biosynthetic process | TAS | biological_process |
| GO:0030170 | Pyridoxal phosphate binding | IEA | molecular_function |
| GO:0034214 | Protein hexamerization | IDA | biological_process |
| GO:0034641 | Cellular nitrogen compound metabolic process | TAS | biological_process |
| GO:0044281 | Small molecule metabolic process | TAS | biological_process |
| GO:0055129 | L-proline biosynthetic process | IEA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.5776933627 | 0.4234829110 | 0.9999902473 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.2244870441 |
| GSE13712_SHEAR | Down | -0.2623226536 |
| GSE13712_STATIC | Down | -0.0588311920 |
| GSE19018 | Up | 0.2420145112 |
| GSE19899_A1 | Down | -0.0879656269 |
| GSE19899_A2 | Up | 0.1557626878 |
| PubMed_21979375_A1 | Down | -0.1608186363 |
| PubMed_21979375_A2 | Down | -0.1750375243 |
| GSE35957 | Up | 0.1208770106 |
| GSE36640 | Up | 0.3152772051 |
| GSE54402 | Up | 0.0312306587 |
| GSE9593 | Up | 0.3333115819 |
| GSE43922 | Down | -0.0279844969 |
| GSE24585 | Up | 0.2859348829 |
| GSE37065 | Down | -0.3603427550 |
| GSE28863_A1 | Down | -0.1715684955 |
| GSE28863_A2 | Up | 0.1451816082 |
| GSE28863_A3 | Down | -0.6487993959 |
| GSE28863_A4 | Up | 0.2412892147 |
| GSE48662 | Down | -0.2970472853 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Name | Drug | Accession number |
|---|---|---|
| L-Ornithine | DB00129 | NUTR00043 |
| Gabaculine | DB02054 | EXPT01542 |
| Canaline | DB02821 | EXPT00828 |
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-1 | MIMAT0000416 | MIRT002736 | Microarray | Functional MTI (Weak) | 15685193 |
| hsa-miR-1 | MIMAT0000416 | MIRT002736 | pSILAC//Proteomics | Functional MTI (Weak) | 18668040 |
| hsa-miR-99b-5p | MIMAT0000689 | MIRT044197 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-196a-5p | MIMAT0000226 | MIRT048267 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
- mirRecord
MicroRNA name | mirBase ID | Target site number | MiRNA mature ID | Test method inter | MiRNA regulation site | Reporter target site | Pubmed ID |
|---|---|---|---|---|---|---|---|
| hsa-miR-1 | MIMAT0000416 | NA | hsa-miR-1 | 15685193 |
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6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
