HCSGD entry for OAS2

1. General information

Official gene symbolOAS2
Entrez ID4939
Gene full name2'-5'-oligoadenylate synthetase 2, 69/71kDa
Other gene symbols
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:00017302'-5'-oligoadenylate synthetase activityIDA IMPmolecular_function
GO:0003725Double-stranded RNA bindingIDA IEA IMPmolecular_function
GO:0005524ATP bindingIEA IMPmolecular_function
GO:0005634NucleusIEAcellular_component
GO:0005737CytoplasmIDAcellular_component
GO:0005739MitochondrionIEAcellular_component
GO:0005783Endoplasmic reticulumIEAcellular_component
GO:0005829CytosolTAScellular_component
GO:0006139Nucleobase-containing compound metabolic processTASbiological_process
GO:0006164Purine nucleotide biosynthetic processIDAbiological_process
GO:0006401RNA catabolic processIEAbiological_process
GO:0006486Protein glycosylationIDAbiological_process
GO:0006955Immune responseIEAbiological_process
GO:0008270Zinc ion bindingIDAmolecular_function
GO:0009615Response to virusTASbiological_process
GO:0016020MembraneTAScellular_component
GO:0016740Transferase activityIEAmolecular_function
GO:0018377Protein myristoylationIMPbiological_process
GO:0019221Cytokine-mediated signaling pathwayTASbiological_process
GO:0043231Intracellular membrane-bounded organelleTAScellular_component
GO:0046872Metal ion bindingIEAmolecular_function
GO:0048471Perinuclear region of cytoplasmIDAcellular_component
GO:0051607Defense response to virusIEAbiological_process
GO:0060333Interferon-gamma-mediated signaling pathwayTASbiological_process
GO:0060337Type I interferon signaling pathwayTASbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.00479535730.30754817830.18217532471.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.1234827495
GSE13712_SHEARUp3.0668323392
GSE13712_STATICUp2.4673691457
GSE19018Down-0.0382053452
GSE19899_A1Up0.0869592283
GSE19899_A2Up0.1148484270
PubMed_21979375_A1Up0.0303519077
PubMed_21979375_A2Up0.0181004023
GSE35957Down-2.5241474103
GSE36640Up1.0344488795
GSE54402Up0.0138781542
GSE9593Up0.3394797581
GSE43922Up0.0109513886
GSE24585Up0.5039694197
GSE37065Up1.6458166478
GSE28863_A1Down-0.5875124477
GSE28863_A2Up2.3086478073
GSE28863_A3Down-0.4245895640
GSE28863_A4Down-0.1026666954
GSE48662Down-0.1114503223

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-335-5pMIMAT0000765MIRT019125MicroarrayFunctional MTI (Weak)18185580
hsa-miR-132-3pMIMAT0000426MIRT021817MicroarrayFunctional MTI (Weak)17612493
hsa-miR-7-5pMIMAT0000252MIRT025932MicroarrayFunctional MTI (Weak)17612493
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    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.