HCSGD entry for ATP2B4
1. General information
| Official gene symbol | ATP2B4 |
|---|---|
| Entrez ID | 493 |
| Gene full name | ATPase, Ca++ transporting, plasma membrane 4 |
| Other gene symbols | ATP2B2 MXRA1 PMCA4 PMCA4b PMCA4x |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0005388 | Calcium-transporting ATPase activity | IEA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005516 | Calmodulin binding | IEA | molecular_function |
| GO:0005524 | ATP binding | IEA | molecular_function |
| GO:0005886 | Plasma membrane | TAS | cellular_component |
| GO:0005887 | Integral component of plasma membrane | TAS | cellular_component |
| GO:0006200 | ATP catabolic process | TAS | biological_process |
| GO:0006810 | Transport | TAS | biological_process |
| GO:0007596 | Blood coagulation | TAS | biological_process |
| GO:0008152 | Metabolic process | TAS | biological_process |
| GO:0017080 | Sodium channel regulator activity | ISS | molecular_function |
| GO:0034220 | Ion transmembrane transport | TAS | biological_process |
| GO:0043234 | Protein complex | ISS | cellular_component |
| GO:0046872 | Metal ion binding | IEA | molecular_function |
| GO:0055085 | Transmembrane transport | TAS | biological_process |
| GO:0097110 | Scaffold protein binding | ISS | molecular_function |
| GO:1902083 | Negative regulation of peptidyl-cysteine S-nitrosylation | NAS | biological_process |
| GO:1902305 | Regulation of sodium ion transmembrane transport | IC | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.1960965617 | 0.0150203298 | 0.8576219638 | 0.2409320950 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.2423557969 |
| GSE13712_SHEAR | Up | 0.0085646594 |
| GSE13712_STATIC | Down | -0.1721126194 |
| GSE19018 | Up | 0.3500611813 |
| GSE19899_A1 | Down | -1.3016734859 |
| GSE19899_A2 | Down | -0.8468594747 |
| PubMed_21979375_A1 | Down | -2.0486722369 |
| PubMed_21979375_A2 | Down | -1.0076620083 |
| GSE35957 | Up | 1.0674486308 |
| GSE36640 | Up | 0.8655200897 |
| GSE54402 | Down | -0.6593126919 |
| GSE9593 | Up | 0.8976027179 |
| GSE43922 | Down | -1.1868820754 |
| GSE24585 | Up | 0.1368509408 |
| GSE37065 | Down | -0.0681532400 |
| GSE28863_A1 | Up | 0.1807666065 |
| GSE28863_A2 | Up | 0.7267825913 |
| GSE28863_A3 | Down | -0.4364127841 |
| GSE28863_A4 | Down | -0.2805254496 |
| GSE48662 | Up | 0.0120067940 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-335-5p | MIMAT0000765 | MIRT017163 | Microarray | Functional MTI (Weak) | 18185580 |
| hsa-miR-1 | MIMAT0000416 | MIRT023603 | Proteomics | Functional MTI (Weak) | 18668040 |
| hsa-miR-21-5p | MIMAT0000076 | MIRT030786 | Microarray | Functional MTI (Weak) | 18591254 |
| hsa-miR-423-5p | MIMAT0004748 | MIRT038088 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 23466301 | In particular, the expression levels of 9 genes, HSP90B1, EID1, ATP2B4, DDAH1, PRNP, RAB1A, PGS5, TM4SF1 and SSR3, gradually increased during senescence |
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