HCSGD entry for NTRK3

1. General information

Official gene symbolNTRK3
Entrez ID4916
Gene full nameneurotrophic tyrosine kinase, receptor, type 3
Other gene symbolsTRKC gp145(trkC)
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000187Activation of MAPK activityIDAbiological_process
GO:0001764Neuron migrationIEAbiological_process
GO:0001933Negative regulation of protein phosphorylationIDAbiological_process
GO:0002039P53 bindingIPImolecular_function
GO:0004714Transmembrane receptor protein tyrosine kinase activityIEAmolecular_function
GO:0005030Neurotrophin receptor activityIDA IEAmolecular_function
GO:0005524ATP bindingIEAmolecular_function
GO:0005737CytoplasmIEAcellular_component
GO:0005886Plasma membraneIEAcellular_component
GO:0005887Integral component of plasma membraneIEAcellular_component
GO:0007169Transmembrane receptor protein tyrosine kinase signaling pathwayIDA IEAbiological_process
GO:0008284Positive regulation of cell proliferationIDAbiological_process
GO:0010628Positive regulation of gene expressionIDAbiological_process
GO:0016020MembraneIEAcellular_component
GO:0019056Modulation by virus of host transcriptionIEAbiological_process
GO:0030335Positive regulation of cell migrationIDAbiological_process
GO:0032148Activation of protein kinase B activityIDAbiological_process
GO:0032856Activation of Ras GTPase activityIDAbiological_process
GO:0033138Positive regulation of peptidyl-serine phosphorylationIDAbiological_process
GO:0038179Neurotrophin signaling pathwayIDAbiological_process
GO:0042490Mechanoreceptor differentiationIEAbiological_process
GO:0043121Neurotrophin bindingTASmolecular_function
GO:0043235Receptor complexIDAcellular_component
GO:0045471Response to ethanolIEAbiological_process
GO:0046777Protein autophosphorylationIEAbiological_process
GO:0046875Ephrin receptor bindingIEAmolecular_function
GO:0048665Neuron fate specificationIEAbiological_process
GO:0048678Response to axon injuryIEAbiological_process
GO:0048691Positive regulation of axon extension involved in regenerationIEAbiological_process
GO:0048712Negative regulation of astrocyte differentiationIEAbiological_process
GO:0050927Positive regulation of positive chemotaxisIDAbiological_process
GO:0051412Response to corticosteroneIEAbiological_process
GO:0060548Negative regulation of cell deathIEAbiological_process
GO:0071300Cellular response to retinoic acidIEAbiological_process
GO:0090102Cochlea developmentIEAbiological_process
GO:2000251Positive regulation of actin cytoskeleton reorganizationIDAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.41431585810.83794160180.99999024731.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.0086677842
GSE13712_SHEARDown-0.0073333523
GSE13712_STATICDown-0.0459147167
GSE19018Up0.1062673341
GSE19899_A1Up0.0371632480
GSE19899_A2Up0.1026984224
PubMed_21979375_A1Down-0.0472056764
PubMed_21979375_A2Down-0.0933252405
GSE35957Up0.4191523436
GSE36640Up0.0477885000
GSE54402Down-0.0557432621
GSE9593Down-0.0411439232
GSE43922Up0.0144796337
GSE24585Up0.0016612902
GSE37065Up0.0668486101
GSE28863_A1Down-0.3827283499
GSE28863_A2Up1.1119369934
GSE28863_A3Up0.0887111783
GSE28863_A4Up0.0363102219
GSE48662Up0.1918316544

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-765MIMAT0003945MIRT000030Luciferase reporter assayFunctional MTI19370765
hsa-miR-485-3pMIMAT0002176MIRT000045Luciferase reporter assayFunctional MTI19370765
hsa-miR-128-3pMIMAT0000424MIRT000340Luciferase reporter assayFunctional MTI19370765
hsa-miR-128-3pMIMAT0000424MIRT000340Luciferase reporter assayFunctional MTI21143953
hsa-miR-9-5pMIMAT0000441MIRT003323Luciferase reporter assay//Western blotFunctional MTI17483472
hsa-miR-9-5pMIMAT0000441MIRT003323Luciferase reporter assayFunctional MTI19188439
hsa-miR-9-5pMIMAT0000441MIRT003323Luciferase reporter assayFunctional MTI18973228
hsa-miR-125b-5pMIMAT0000423MIRT003754Luciferase reporter assay//Western blot//Reporter assayFunctional MTI17483472
hsa-miR-125a-5pMIMAT0000443MIRT003755Luciferase reporter assay//Western blotFunctional MTI17483472
hsa-miR-125a-5pMIMAT0000443MIRT003755Luciferase reporter assayFunctional MTI19179615
hsa-miR-125a-5pMIMAT0000443MIRT003755Luciferase reporter assayFunctional MTI18973228
hsa-miR-617MIMAT0003286MIRT004881Luciferase reporter assayNon-Functional MTI19370765
hsa-miR-345-5pMIMAT0000772MIRT004882Luciferase reporter assayNon-Functional MTI19370765
hsa-miR-384MIMAT0001075MIRT004909Luciferase reporter assayNon-Functional MTI19370765
hsa-miR-330-3pMIMAT0000751MIRT004910Luciferase reporter assayNon-Functional MTI19370765
hsa-miR-198MIMAT0000228MIRT004911Luciferase reporter assayNon-Functional MTI19370765
hsa-miR-625-5pMIMAT0003294MIRT004914Luciferase reporter assayFunctional MTI19370765
hsa-miR-509-3pMIMAT0002881MIRT004915Luciferase reporter assayFunctional MTI19370765
hsa-miR-509-3pMIMAT0002881MIRT004915Luciferase reporter assayFunctional MTI21143953
hsa-miR-151a-3pMIMAT0000757MIRT005962Luciferase reporter assayFunctional MTI21143953
hsa-miR-185-5pMIMAT0000455MIRT005963Luciferase reporter assayFunctional MTI21143953
hsa-miR-615-3pMIMAT0003283MIRT040195CLASHFunctional MTI (Weak)23622248
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    • mirRecord

MicroRNA name

mirBase ID

Target site number

MiRNA mature ID

Test method inter

MiRNA regulation site

Reporter target site

Pubmed ID

hsa-miR-9-5pMIMAT00004411hsa-miR-9{Western blot}{Western blot}{overexpression by miRNA precursor transfection}{underexpression by LNA antisense miRNA oligonucleotides}17483472
hsa-miR-125b-5pMIMAT00004231hsa-miR-125b{Western blot}{Western blot}{overexpression by miRNA precursor transfection}{underexpression by LNA antisense miRNA oligonucleotides}17483472
hsa-miR-485-3pMIMAT00021761hsa-miR-485-3p19370765
hsa-miR-509-3pMIMAT00028811hsa-miR-509-3p19370765
hsa-miR-625-5pMIMAT00032941hsa-miR-62519370765
hsa-miR-765MIMAT00039451hsa-miR-76519370765
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6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.