HCSGD entry for NTHL1
1. General information
| Official gene symbol | NTHL1 |
|---|---|
| Entrez ID | 4913 |
| Gene full name | nth endonuclease III-like 1 (E. coli) |
| Other gene symbols | NTH1 OCTS3 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0003677 | DNA binding | IEA | molecular_function |
| GO:0003690 | Double-stranded DNA binding | IDA | molecular_function |
| GO:0003824 | Catalytic activity | IEA | molecular_function |
| GO:0003906 | DNA-(apurinic or apyrimidinic site) lyase activity | IDA | molecular_function |
| GO:0004519 | Endonuclease activity | TAS | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005634 | Nucleus | IDA | cellular_component |
| GO:0005654 | Nucleoplasm | TAS | cellular_component |
| GO:0005739 | Mitochondrion | IEA | cellular_component |
| GO:0006281 | DNA repair | TAS | biological_process |
| GO:0006284 | Base-excision repair | IEA TAS | biological_process |
| GO:0006285 | Base-excision repair, AP site formation | IDA TAS | biological_process |
| GO:0006296 | Nucleotide-excision repair, DNA incision, 5'-to lesion | IDA | biological_process |
| GO:0019104 | DNA N-glycosylase activity | IDA | molecular_function |
| GO:0045008 | Depyrimidination | TAS | biological_process |
| GO:0046872 | Metal ion binding | IEA | molecular_function |
| GO:0051539 | 4 iron, 4 sulfur cluster binding | IEA | molecular_function |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.8938571559 | 0.1420856274 | 0.9999902473 | 0.7251960054 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.0096071108 |
| GSE13712_SHEAR | Down | -0.1964287416 |
| GSE13712_STATIC | Down | -0.1887424890 |
| GSE19018 | Up | 0.1044654763 |
| GSE19899_A1 | Down | -0.2271904210 |
| GSE19899_A2 | Up | 0.1509153159 |
| PubMed_21979375_A1 | Up | 0.6424392323 |
| PubMed_21979375_A2 | Up | 0.0503521965 |
| GSE35957 | Down | -0.3851932876 |
| GSE36640 | Down | -0.0712203577 |
| GSE54402 | Down | -0.0631999441 |
| GSE9593 | Down | -0.5591312411 |
| GSE43922 | Down | -0.0012584814 |
| GSE24585 | Down | -0.6601920385 |
| GSE37065 | Down | -0.1624699090 |
| GSE28863_A1 | Down | -0.1510512903 |
| GSE28863_A2 | Down | -0.1743179070 |
| GSE28863_A3 | Up | 0.1420156829 |
| GSE28863_A4 | Up | 0.1568428253 |
| GSE48662 | Up | 0.0807922031 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-124-3p | MIMAT0000422 | MIRT022743 | Proteomics | Functional MTI (Weak) | 18668037 |
| hsa-miR-16-5p | MIMAT0000069 | MIRT031740 | Proteomics | Functional MTI (Weak) | 18668040 |
| hsa-miR-93-5p | MIMAT0000093 | MIRT048860 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-92a-3p | MIMAT0000092 | MIRT049546 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
