HCSGD entry for SLC11A2

1. General information

Official gene symbolSLC11A2
Entrez ID4891
Gene full namesolute carrier family 11 (proton-coupled divalent metal ion transporters), member 2
Other gene symbolsDCT1 DMT1 NRAMP2
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

color bar
This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0001666Response to hypoxiaIEPbiological_process
GO:0003032Detection of oxygenIEPbiological_process
GO:0005215Transporter activityIEAmolecular_function
GO:0005375Copper ion transmembrane transporter activityIDA IEAmolecular_function
GO:0005384Manganese ion transmembrane transporter activityIDA IEAmolecular_function
GO:0005385Zinc ion transmembrane transporter activityIDAmolecular_function
GO:0005506Iron ion bindingIEAmolecular_function
GO:0005507Copper ion bindingIEAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005634NucleusIDAcellular_component
GO:0005737CytoplasmIDAcellular_component
GO:0005764LysosomeIDAcellular_component
GO:0005765Lysosomal membraneIDA IEAcellular_component
GO:0005769Early endosomeIDA IEAcellular_component
GO:0005770Late endosomeIDAcellular_component
GO:0005773VacuoleIMPcellular_component
GO:0005802Trans-Golgi networkIDAcellular_component
GO:0005886Plasma membraneIDA IMP TAScellular_component
GO:0005887Integral component of plasma membraneIEAcellular_component
GO:0005903Brush borderIEAcellular_component
GO:0006783Heme biosynthetic processIEAbiological_process
GO:0006824Cobalt ion transportIDAbiological_process
GO:0006825Copper ion transportIDAbiological_process
GO:0006828Manganese ion transportIDAbiological_process
GO:0006879Cellular iron ion homeostasisTASbiological_process
GO:0006919Activation of cysteine-type endopeptidase activity involved in apoptotic processIDAbiological_process
GO:0007611Learning or memoryIEAbiological_process
GO:0008270Zinc ion bindingIEAmolecular_function
GO:0009986Cell surfaceIDA IEAcellular_component
GO:0010039Response to iron ionIEPbiological_process
GO:0010042Response to manganese ionIEAbiological_process
GO:0010288Response to lead ionIEAbiological_process
GO:0012505Endomembrane systemIEAcellular_component
GO:0015078Hydrogen ion transmembrane transporter activityIEAmolecular_function
GO:0015085Calcium ion transmembrane transporter activityIDAmolecular_function
GO:0015086Cadmium ion transmembrane transporter activityIDA IEAmolecular_function
GO:0015087Cobalt ion transmembrane transporter activityIDA IEAmolecular_function
GO:0015093Ferrous iron transmembrane transporter activityIDA IEAmolecular_function
GO:0015094Lead ion transmembrane transporter activityIDA IEAmolecular_function
GO:0015099Nickel cation transmembrane transporter activityIDA IEAmolecular_function
GO:0015100Vanadium ion transmembrane transporter activityIDAmolecular_function
GO:0015295Solute:hydrogen symporter activityIDAmolecular_function
GO:0015675Nickel cation transportIDAbiological_process
GO:0015676Vanadium ion transportIDAbiological_process
GO:0015684Ferrous iron transportIDAbiological_process
GO:0015692Lead ion transportIDAbiological_process
GO:0016020MembraneIEAcellular_component
GO:0016151Nickel cation bindingIEAmolecular_function
GO:0016324Apical plasma membraneIDAcellular_component
GO:0022890Inorganic cation transmembrane transporter activityIGImolecular_function
GO:0030145Manganese ion bindingIEAmolecular_function
GO:0031410Cytoplasmic vesicleIDAcellular_component
GO:0031902Late endosome membraneIDA IEAcellular_component
GO:0034599Cellular response to oxidative stressIDAbiological_process
GO:0035444Nickel cation transmembrane transportIDAbiological_process
GO:0045177Apical part of cellIDA IEAcellular_component
GO:0045178Basal part of cellIDAcellular_component
GO:0046686Response to cadmium ionIEAbiological_process
GO:0046870Cadmium ion bindingIEAmolecular_function
GO:0048471Perinuclear region of cytoplasmIDAcellular_component
GO:0048813Dendrite morphogenesisIEAbiological_process
GO:0048821Erythrocyte developmentIEAbiological_process
GO:0050897Cobalt ion bindingIEAmolecular_function
GO:0055037Recycling endosomeIDA IEAcellular_component
GO:0055085Transmembrane transportTASbiological_process
GO:0060586Multicellular organismal iron ion homeostasisIEA IMPbiological_process
GO:0070574Cadmium ion transmembrane transportIDAbiological_process
GO:0070627Ferrous iron importIDA IEAbiological_process
GO:0070826Paraferritin complexIDAcellular_component
GO:0070835Chromium ion transmembrane transporter activityIDAmolecular_function
GO:0071281Cellular response to iron ionIEAbiological_process
GO:0071356Cellular response to tumor necrosis factorIEAbiological_process
GO:0071421Manganese ion transmembrane transportIDAbiological_process
GO:0071456Cellular response to hypoxiaIEAbiological_process
GO:0071577Zinc ion transmembrane transportIDAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.01563012800.97246957180.30978960841.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.1750736742
GSE13712_SHEARDown-0.2930915274
GSE13712_STATICDown-0.0461152100
GSE19018Up0.1201806320
GSE19899_A1Up0.1672686655
GSE19899_A2Up1.0539445778
PubMed_21979375_A1Up0.4411497096
PubMed_21979375_A2Up1.0003930713
GSE35957Up0.3329664886
GSE36640Up0.5517628187
GSE54402Up0.2239049117
GSE9593Up1.1626405952
GSE43922Up0.1327572434
GSE24585Down-0.0364043251
GSE37065Up0.4355847839
GSE28863_A1Up0.3263658382
GSE28863_A2Up0.3552478237
GSE28863_A3Down-0.5791061491
GSE28863_A4Up0.1426275903
GSE48662Down-0.0795625399

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-let-7d-5pMIMAT0000065MIRT004505qRT-PCR//Luciferase reporter assay//Western blotFunctional MTI20410187
hsa-miR-374b-5pMIMAT0004955MIRT016064SequencingFunctional MTI (Weak)20371350
hsa-miR-484MIMAT0002174MIRT016623SequencingFunctional MTI (Weak)20371350
hsa-miR-484MIMAT0002174MIRT016623CLASHFunctional MTI (Weak)23622248
hsa-miR-423-3pMIMAT0001340MIRT016685SequencingFunctional MTI (Weak)20371350
hsa-miR-122-5pMIMAT0000421MIRT023294MicroarrayFunctional MTI (Weak)17612493
hsa-miR-218-5pMIMAT0000275MIRT024231SequencingFunctional MTI (Weak)20371350
hsa-miR-24-3pMIMAT0000080MIRT030520MicroarrayFunctional MTI (Weak)19748357
hsa-miR-16-5pMIMAT0000069MIRT031729SequencingFunctional MTI (Weak)20371350
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    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.