HCSGD entry for NPY6R
1. General information
| Official gene symbol | NPY6R |
|---|---|
| Entrez ID | 4888 |
| Gene full name | neuropeptide Y receptor Y6 (pseudogene) |
| Other gene symbols | NPY1RL NPY6RP PP2 Y2B |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0004983 | Neuropeptide Y receptor activity | IKR | molecular_function |
| GO:0007186 | G-protein coupled receptor signaling pathway | IKR | biological_process |
| GO:0016021 | Integral component of membrane | IEA | cellular_component |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.9148759128 | 0.5522466890 | 0.9999902473 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.0837792285 |
| GSE13712_SHEAR | Down | -0.0151271044 |
| GSE13712_STATIC | Down | -0.1225756665 |
| GSE19018 | Down | -0.1344861114 |
| GSE19899_A1 | Up | 0.0276008070 |
| GSE19899_A2 | Up | 0.1298690807 |
| PubMed_21979375_A1 | Down | -0.1157143793 |
| PubMed_21979375_A2 | Down | -0.0497422203 |
| GSE35957 | Up | 0.1640119181 |
| GSE36640 | Down | -0.0268737039 |
| GSE54402 | Up | 0.0417165733 |
| GSE9593 | Up | 0.0262932048 |
| GSE43922 | Up | 0.0118351636 |
| GSE24585 | Down | -0.0622213517 |
| GSE37065 | Up | 0.0423030313 |
| GSE28863_A1 | Down | -0.0753610826 |
| GSE28863_A2 | Down | -0.0924426890 |
| GSE28863_A3 | Up | 0.1499597399 |
| GSE28863_A4 | Up | 0.0036404045 |
| GSE48662 | Down | -0.1889006050 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
No target information from mirTarBase
- mirTarBase
- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 2 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 25203674 | Using PP2 (4-Amino-5-(4-chlorophenyl)-7-(t-butyl)pyrazolo[3,4-d]pyrimidine) pyrimidine or Akt inhibitors, inhibitors of the nonreceptor tyrosine kinase Src or Akt, known interaction partners of AR, reduced the level of androgen-induced cellular senescence, suggesting a partly nongenomic pathway to induce cellular senescence by AA |
| 14963003 | Moreover, the induction of premature senescence by low concentrations of H2O2 was completely blocked with the Src-family kinase inhibitor PP2, suggesting a crucial role for Src-family kinases in the induction of endothelial cell aging |
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