HCSGD entry for NPR3

1. General information

Official gene symbolNPR3
Entrez ID4883
Gene full namenatriuretic peptide receptor C/guanylate cyclase C (atrionatriuretic peptide receptor C)
Other gene symbolsANP-C ANPR-C ANPRC C5orf23 GUCY2B NPR-C NPRC
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

color bar
This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0001501Skeletal system developmentISSbiological_process
GO:0002158Osteoclast proliferationISSbiological_process
GO:0005887Integral component of plasma membraneICcellular_component
GO:0007193Adenylate cyclase-inhibiting G-protein coupled receptor signaling pathwayIEAbiological_process
GO:0007194Negative regulation of adenylate cyclase activityIEAbiological_process
GO:0007200Phospholipase C-activating G-protein coupled receptor signaling pathwayIEAbiological_process
GO:0008217Regulation of blood pressureISSbiological_process
GO:0008528G-protein coupled peptide receptor activityISSmolecular_function
GO:0016021Integral component of membraneIEAcellular_component
GO:0016941Natriuretic peptide receptor activityIDAmolecular_function
GO:0017046Peptide hormone bindingISSmolecular_function
GO:0030157Pancreatic juice secretionIEAbiological_process
GO:0033688Regulation of osteoblast proliferationISSbiological_process
GO:0035810Positive regulation of urine volumeISSbiological_process
GO:0042562Hormone bindingIPImolecular_function
GO:0042803Protein homodimerization activityIEAmolecular_function
GO:0048015Phosphatidylinositol-mediated signalingIEAbiological_process
GO:0048662Negative regulation of smooth muscle cell proliferationIEAbiological_process
GO:0051000Positive regulation of nitric-oxide synthase activityISSbiological_process
Entries Per Page
Displaying Page of

4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.37607707910.00057195020.99999024730.0450247761

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.0907521632
GSE13712_SHEARDown-0.0345180864
GSE13712_STATICDown-0.1110262946
GSE19018Up0.0927732529
GSE19899_A1Down-0.4824836897
GSE19899_A2Down-3.5060295628
PubMed_21979375_A1Down-3.4644081048
PubMed_21979375_A2Down-2.2735882342
GSE35957Up0.2672878276
GSE36640Down-1.6388008327
GSE54402Down-2.7209934785
GSE9593Down-0.5331476021
GSE43922Down-2.7732527614
GSE24585Up0.3489359359
GSE37065Down-0.6803115435
GSE28863_A1Up0.3527402883
GSE28863_A2Up1.6612592207
GSE28863_A3Down-0.7754662600
GSE28863_A4Down-0.0157149422
GSE48662Up0.6305961359

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

NesiritideDB04899 -

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-16-5pMIMAT0000069MIRT001435pSILAC//Proteomics;OtherFunctional MTI (Weak)18668040
hsa-miR-30a-5pMIMAT0000087MIRT005159pSILAC//Proteomics;OtherFunctional MTI (Weak)18668040
hsa-miR-335-5pMIMAT0000765MIRT017512MicroarrayFunctional MTI (Weak)18185580
hsa-miR-98-5pMIMAT0000096MIRT027551MicroarrayFunctional MTI (Weak)19088304
Entries Per Page
Displaying Page of
    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.