HCSGD entry for ATP2A2

1. General information

Official gene symbolATP2A2
Entrez ID488
Gene full nameATPase, Ca++ transporting, cardiac muscle, slow twitch 2
Other gene symbolsATP2B DAR DD SERCA2
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

color bar
This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0002026Regulation of the force of heart contractionIEAbiological_process
GO:0005388Calcium-transporting ATPase activityIEA TASmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005524ATP bindingIEAmolecular_function
GO:0005789Endoplasmic reticulum membraneIDA TAScellular_component
GO:0005887Integral component of plasma membraneTAScellular_component
GO:0006200ATP catabolic processTASbiological_process
GO:0006810TransportTASbiological_process
GO:0006874Cellular calcium ion homeostasisTASbiological_process
GO:0006984ER-nucleus signaling pathwayIEAbiological_process
GO:0007155Cell adhesionTASbiological_process
GO:0007596Blood coagulationTASbiological_process
GO:0008022Protein C-terminus bindingIPImolecular_function
GO:0008152Metabolic processTASbiological_process
GO:0008544Epidermis developmentTASbiological_process
GO:0010460Positive regulation of heart rateTASbiological_process
GO:0016020MembraneIDAcellular_component
GO:0016021Integral component of membraneIEAcellular_component
GO:0016529Sarcoplasmic reticulumIDAcellular_component
GO:0019899Enzyme bindingIPImolecular_function
GO:0031095Platelet dense tubular network membraneTAScellular_component
GO:0033017Sarcoplasmic reticulum membraneTAScellular_component
GO:0034220Ion transmembrane transportTASbiological_process
GO:0043231Intracellular membrane-bounded organelleTAScellular_component
GO:0044548S100 protein bindingIPImolecular_function
GO:0045822Negative regulation of heart contractionIEAbiological_process
GO:0046872Metal ion bindingIEAmolecular_function
GO:0055085Transmembrane transportTASbiological_process
GO:0055119Relaxation of cardiac muscleTASbiological_process
GO:0070296Sarcoplasmic reticulum calcium ion transportTASbiological_process
GO:0070588Calcium ion transmembrane transportTASbiological_process
GO:0086036Regulation of cardiac muscle cell membrane potentialTASbiological_process
GO:0086039Calcium-transporting ATPase activity involved in regulation of cardiac muscle cell membrane potentialTASmolecular_function
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.33133658300.04963149580.99999024730.4168317167

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.6470751732
GSE13712_SHEARDown-0.2368667236
GSE13712_STATICDown-0.0981414960
GSE19018Down-0.2195479201
GSE19899_A1Down-0.5030768942
GSE19899_A2Down-0.4374585372
PubMed_21979375_A1Down-1.3417634394
PubMed_21979375_A2Down-0.3642477089
GSE35957Up0.5325968661
GSE36640Up0.0856167881
GSE54402Down-0.4419381762
GSE9593Down-0.2461827441
GSE43922Up0.0992380229
GSE24585Up0.0439071104
GSE37065Down-0.0414819527
GSE28863_A1Up1.4596960514
GSE28863_A2Up1.0232568046
GSE28863_A3Down-0.0220191723
GSE28863_A4Down-0.0764385122
GSE48662Down-0.1243164422

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-30a-5pMIMAT0000087MIRT005137pSILAC//Proteomics;OtherFunctional MTI (Weak)18668040
hsa-miR-142-3pMIMAT0000434MIRT021642MicroarrayFunctional MTI (Weak)17612493
hsa-miR-26b-5pMIMAT0000083MIRT028977MicroarrayFunctional MTI (Weak)19088304
hsa-let-7b-5pMIMAT0000063MIRT032246ProteomicsFunctional MTI (Weak)18668040
hsa-let-7b-5pMIMAT0000063MIRT032246CLASHFunctional MTI (Weak)23622248
hsa-miR-1226-3pMIMAT0005577MIRT036518CLASHFunctional MTI (Weak)23622248
hsa-miR-671-5pMIMAT0003880MIRT039280CLASHFunctional MTI (Weak)23622248
hsa-miR-484MIMAT0002174MIRT042367CLASHFunctional MTI (Weak)23622248
hsa-miR-15b-5pMIMAT0000417MIRT046495CLASHFunctional MTI (Weak)23622248
hsa-miR-221-3pMIMAT0000278MIRT046967CLASHFunctional MTI (Weak)23622248
hsa-miR-197-3pMIMAT0000227MIRT048071CLASHFunctional MTI (Weak)23622248
hsa-miR-100-5pMIMAT0000098MIRT048397CLASHFunctional MTI (Weak)23622248
hsa-miR-31-5pMIMAT0000089MIRT049871CLASHFunctional MTI (Weak)23622248
hsa-let-7f-5pMIMAT0000067MIRT051398CLASHFunctional MTI (Weak)23622248
hsa-let-7c-5pMIMAT0000064MIRT051808CLASHFunctional MTI (Weak)23622248
hsa-let-7a-5pMIMAT0000062MIRT052513CLASHFunctional MTI (Weak)23622248
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    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 2 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

19730126Levosimendan also ameliorated MI-induced atrial natriuretic peptide, IL-6, and connective tissue growth factor overexpression as well as MI-induced disturbances in calcium-handling proteins (SERCA2, Na-Ca exchanger) without changes in diabetic status or systemic blood pressure
12887974Since concentrations of SERCA2a and SERCA2b proteins were similar in young and senescent cells, slow rate of Ca2+ decay and high diastolic [Ca2+]c are explained on the assumption that the usual Ca2+ stimulation of SERCA2 activity is attenuated in senescent cells
12887974The prolonged time-to-peak [Ca2+]c is discussed to result from insufficient SR Ca2+ filling by SERCA2 and, in context with confocal images, from a shift of the SERCA2b distribution to the subsarcolemmal space
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