HCSGD entry for NPHS1

1. General information

Official gene symbolNPHS1
Entrez ID4868
Gene full namenephrosis 1, congenital, Finnish type (nephrin)
Other gene symbolsCNF NPHN nephrin
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0005515Protein bindingIPImolecular_function
GO:0005886Plasma membraneIDA ISS TAScellular_component
GO:0005887Integral component of plasma membraneTAScellular_component
GO:0007155Cell adhesionIEAbiological_process
GO:0007254JNK cascadeIEAbiological_process
GO:0007519Skeletal muscle tissue developmentIEAbiological_process
GO:0007520Myoblast fusionIEAbiological_process
GO:0007588ExcretionTASbiological_process
GO:0017022Myosin bindingIPImolecular_function
GO:0019904Protein domain specific bindingIEAmolecular_function
GO:0030507Spectrin bindingIEAmolecular_function
GO:0030838Positive regulation of actin filament polymerizationIEAbiological_process
GO:0032836Glomerular basement membrane developmentIEPbiological_process
GO:0036057Slit diaphragmISScellular_component
GO:0042995Cell projectionIEAcellular_component
GO:0043234Protein complexIEAcellular_component
GO:0044062Regulation of excretionIEAbiological_process
GO:0045121Membrane raftIEAcellular_component
GO:0051393Alpha-actinin bindingIEAmolecular_function
GO:0072015Glomerular visceral epithelial cell developmentIEPbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.69014855440.68769104520.99999024731.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.0812972046
GSE13712_SHEARUp0.1149484486
GSE13712_STATICUp0.1601252411
GSE19018Up0.0114178895
GSE19899_A1Up0.0078694058
GSE19899_A2Up0.0277205291
PubMed_21979375_A1Down-0.0272470329
PubMed_21979375_A2Down-0.1849203829
GSE35957Down-0.0491577635
GSE36640Up0.1532918910
GSE54402Down-0.0689612411
GSE9593Down-0.1114556535
GSE43922Up0.1328041496
GSE24585Down-0.0337300920
GSE37065Down-0.0690098024
GSE28863_A1Down-0.1273163305
GSE28863_A2Down-0.2102212075
GSE28863_A3Up0.2906172358
GSE28863_A4Up0.1576426543
GSE48662Down-0.0181660370

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

    • mirTarBase
No target information from mirTarBase
    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.