HCSGD entry for PNP
1. General information
| Official gene symbol | PNP |
|---|---|
| Entrez ID | 4860 |
| Gene full name | purine nucleoside phosphorylase |
| Other gene symbols | NP PRO1837 PUNP |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0001882 | Nucleoside binding | IDA | molecular_function |
| GO:0002060 | Purine nucleobase binding | IDA | molecular_function |
| GO:0004731 | Purine-nucleoside phosphorylase activity | EXP IDA IEA | molecular_function |
| GO:0005622 | Intracellular | IDA | cellular_component |
| GO:0005737 | Cytoplasm | IDA | cellular_component |
| GO:0005829 | Cytosol | TAS | cellular_component |
| GO:0005856 | Cytoskeleton | IEA | cellular_component |
| GO:0006139 | Nucleobase-containing compound metabolic process | IDA | biological_process |
| GO:0006144 | Purine nucleobase metabolic process | TAS | biological_process |
| GO:0006148 | Inosine catabolic process | IDA | biological_process |
| GO:0006195 | Purine nucleotide catabolic process | TAS | biological_process |
| GO:0006738 | Nicotinamide riboside catabolic process | IDA | biological_process |
| GO:0006955 | Immune response | IMP | biological_process |
| GO:0008144 | Drug binding | IDA | molecular_function |
| GO:0009116 | Nucleoside metabolic process | IEA | biological_process |
| GO:0034356 | NAD biosynthesis via nicotinamide riboside salvage pathway | IGI | biological_process |
| GO:0034418 | Urate biosynthetic process | IDA | biological_process |
| GO:0042102 | Positive regulation of T cell proliferation | IDA | biological_process |
| GO:0042301 | Phosphate ion binding | IDA | molecular_function |
| GO:0042493 | Response to drug | IDA IMP | biological_process |
| GO:0043101 | Purine-containing compound salvage | TAS | biological_process |
| GO:0044281 | Small molecule metabolic process | TAS | biological_process |
| GO:0046638 | Positive regulation of alpha-beta T cell differentiation | IDA | biological_process |
| GO:0055086 | Nucleobase-containing small molecule metabolic process | TAS | biological_process |
| GO:0070970 | Interleukin-2 secretion | IMP | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.0000477148 | 0.7661372098 | 0.0188913043 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 2.6716149232 |
| GSE13712_SHEAR | Up | 0.4022806488 |
| GSE13712_STATIC | Up | 0.4210164430 |
| GSE19018 | Up | 0.0431857279 |
| GSE19899_A1 | Up | 3.7024862254 |
| GSE19899_A2 | Up | 2.5351329981 |
| PubMed_21979375_A1 | Up | 3.4182885358 |
| PubMed_21979375_A2 | Up | 2.5657967247 |
| GSE35957 | Down | -0.3492039874 |
| GSE36640 | Up | 0.2876109561 |
| GSE54402 | Up | 3.2344846536 |
| GSE9593 | Up | 0.3281947564 |
| GSE43922 | Up | 2.5272127729 |
| GSE24585 | Down | -0.0205176084 |
| GSE37065 | Up | 0.7339871543 |
| GSE28863_A1 | Down | -0.8741894277 |
| GSE28863_A2 | Up | 0.5866542901 |
| GSE28863_A3 | Down | -0.5587870057 |
| GSE28863_A4 | Up | 0.4694552388 |
| GSE48662 | Down | -0.5617652358 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
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- Drugs
Name | Drug | Accession number |
|---|---|---|
| 8-azaguanine | DB01667 | EXPT00603 |
| 2,6-Diamino-(S)-9-[2-(Phosphonomethoxy)Propyl]Purine | DB02222 | EXPT00361 |
| Immucillin-G | DB02230 | EXPT01868 |
| Guanine | DB02377 | EXPT01672 |
| 2-Amino-7-[2-(2-Hydroxy-1-Hydroxymethyl-Ethylamino)-Ethyl]-1,7-Dihydro-Purin-6-One | DB02391 | EXPT01667 |
| Peldesine | DB02568 | EXPT03305 | DB07442 |
| 9-Deazainosine | DB02796 | EXPT00357 |
| Guanosine | DB02857 | EXPT01622 |
| Ribose-1-Phosphate | DB03101 | EXPT02743 |
| 4'-Deaza-1'-Aza-2'-Deoxy-1'-(9-Methylene)-Immucillin-H, (3r,4r)-N-[9-Deazahypoxanthin-9-Yl)Methyl]-4-Hydroxymethyl-Pyrrolidin-3-Ol | DB03551 | EXPT01206 |
| 3-Deoxyguanosine | DB03609 | EXPT00167 |
| MT-Immucillin-H | DB03881 | EXPT02245 |
| Hypoxanthine | DB04076 | EXPT01767 |
| 9-(5,5-Difluoro-5-Phosphonopentyl)Guanine | DB04260 | EXPT01684 |
| Inosine | DB04335 | EXPT02378 |
| 9-DEAZAINOSINE-2',3'-O-ETHYLIDENEPHOSPHONATE | DB04753 | - |
| GUANOSINE-2',3'-O-ETHYLIDENEPHOSPHONATE | DB04754 | - |
| GUANOSINE-2',3'-O-METHYLIDENEPHOSPHONATE | DB04757 | - |
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-133a-3p | MIMAT0000427 | MIRT006571 | Luciferase reporter assay//Western blot | Functional MTI | 22068816 |
| hsa-miR-133a-3p | MIMAT0000427 | MIRT006571 | Western blot;qRT-PCR;Microarray | Functional MTI | 21701775 |
| hsa-miR-1 | MIMAT0000416 | MIRT003765 | Microarray | Functional MTI (Weak) | 15685193 |
| hsa-miR-1 | MIMAT0000416 | MIRT003765 | Luciferase reporter assay//Western blot | Functional MTI | 22068816 |
| hsa-miR-1 | MIMAT0000416 | MIRT003765 | Microarray | Functional MTI (Weak) | 18668037 |
| hsa-miR-1 | MIMAT0000416 | MIRT003765 | Proteomics | Functional MTI (Weak) | 18668040 |
| hsa-miR-1 | MIMAT0000416 | MIRT003765 | Western blot;qRT-PCR;Microarray | Functional MTI | 21701775 |
| hsa-miR-186-5p | MIMAT0000456 | MIRT021132 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-124-3p | MIMAT0000422 | MIRT022705 | Microarray | Functional MTI (Weak) | 18668037 |
| hsa-miR-196a-5p | MIMAT0000226 | MIRT026040 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-16-5p | MIMAT0000069 | MIRT031731 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-16-5p | MIMAT0000069 | MIRT031731 | Proteomics | Functional MTI (Weak) | 18668040 |
| hsa-miR-1296-5p | MIMAT0005794 | MIRT036138 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
