HCSGD entry for NOTCH3
1. General information
| Official gene symbol | NOTCH3 |
|---|---|
| Entrez ID | 4854 |
| Gene full name | notch 3 |
| Other gene symbols | CADASIL CASIL |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000139 | Golgi membrane | TAS | cellular_component |
| GO:0005509 | Calcium ion binding | IEA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005576 | Extracellular region | TAS | cellular_component |
| GO:0005654 | Nucleoplasm | TAS | cellular_component |
| GO:0005789 | Endoplasmic reticulum membrane | TAS | cellular_component |
| GO:0005829 | Cytosol | TAS | cellular_component |
| GO:0005886 | Plasma membrane | TAS | cellular_component |
| GO:0006355 | Regulation of transcription, DNA-templated | IEA | biological_process |
| GO:0006367 | Transcription initiation from RNA polymerase II promoter | TAS | biological_process |
| GO:0007219 | Notch signaling pathway | TAS | biological_process |
| GO:0007220 | Notch receptor processing | TAS | biological_process |
| GO:0010467 | Gene expression | TAS | biological_process |
| GO:0016021 | Integral component of membrane | IEA | cellular_component |
| GO:0019899 | Enzyme binding | IEA | molecular_function |
| GO:0030900 | Forebrain development | IEA | biological_process |
| GO:0043235 | Receptor complex | IDA | cellular_component |
| GO:0045665 | Negative regulation of neuron differentiation | IEA | biological_process |
| GO:0048661 | Positive regulation of smooth muscle cell proliferation | IEA | biological_process |
| GO:0048663 | Neuron fate commitment | IEA | biological_process |
| GO:0072104 | Glomerular capillary formation | IEA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.6783311234 | 0.0219740549 | 0.9999902473 | 0.2856193086 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.2757729029 |
| GSE13712_SHEAR | Down | -0.5770675011 |
| GSE13712_STATIC | Down | -0.5733956002 |
| GSE19018 | Up | 0.7703848383 |
| GSE19899_A1 | Down | -0.4137441497 |
| GSE19899_A2 | Down | -0.2925517211 |
| PubMed_21979375_A1 | Down | -1.0706516271 |
| PubMed_21979375_A2 | Down | -0.3749613440 |
| GSE35957 | Down | -0.6400020164 |
| GSE36640 | Down | -0.6914922999 |
| GSE54402 | Down | -0.2533925389 |
| GSE9593 | Down | -0.0168329682 |
| GSE43922 | Down | -0.2758735633 |
| GSE24585 | Up | 0.3998936505 |
| GSE37065 | Down | -0.1975108978 |
| GSE28863_A1 | Up | 0.1618705706 |
| GSE28863_A2 | Up | 0.0595785273 |
| GSE28863_A3 | Up | 0.0969039776 |
| GSE28863_A4 | Down | -0.0755592621 |
| GSE48662 | Up | 0.6573639210 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-206 | MIMAT0000462 | MIRT000665 | Luciferase reporter assay//qRT-PCR//Western blot//Reporter assay | Functional MTI | 19723635 |
| hsa-miR-1 | MIMAT0000416 | MIRT006550 | Immunoblot//Immunofluorescence//Immunoprecipitaion//Luciferase reporter assay//Microarray//qRT-PCR//Western blot | Functional MTI | 22210864 |
| hsa-miR-150-5p | MIMAT0000451 | MIRT007016 | Luciferase reporter assay | Functional MTI | 21551231 |
| hsa-miR-335-5p | MIMAT0000765 | MIRT017387 | Microarray | Functional MTI (Weak) | 18185580 |
| hsa-miR-484 | MIMAT0002174 | MIRT042194 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
