HCSGD entry for CNOT4
1. General information
| Official gene symbol | CNOT4 |
|---|---|
| Entrez ID | 4850 |
| Gene full name | CCR4-NOT transcription complex, subunit 4 |
| Other gene symbols | CLONE243 NOT4 NOT4H |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000166 | Nucleotide binding | IEA | molecular_function |
| GO:0000288 | Nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay | TAS | biological_process |
| GO:0000289 | Nuclear-transcribed mRNA poly(A) tail shortening | TAS | biological_process |
| GO:0003723 | RNA binding | IEA | molecular_function |
| GO:0004842 | Ubiquitin-protein ligase activity | IDA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005634 | Nucleus | IEA | cellular_component |
| GO:0005829 | Cytosol | TAS | cellular_component |
| GO:0008270 | Zinc ion binding | IEA | molecular_function |
| GO:0010467 | Gene expression | TAS | biological_process |
| GO:0016070 | RNA metabolic process | TAS | biological_process |
| GO:0016071 | MRNA metabolic process | TAS | biological_process |
| GO:0030014 | CCR4-NOT complex | IDA | cellular_component |
| GO:0051865 | Protein autoubiquitination | IDA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.0951959158 | 0.9697431595 | 0.6459530034 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.0670044813 |
| GSE13712_SHEAR | Up | 0.1261816575 |
| GSE13712_STATIC | Up | 0.2577827353 |
| GSE19018 | Up | 0.1038159582 |
| GSE19899_A1 | Up | 0.0885811024 |
| GSE19899_A2 | Up | 0.3700722606 |
| PubMed_21979375_A1 | Up | 0.0637861446 |
| PubMed_21979375_A2 | Up | 0.3418905329 |
| GSE35957 | Up | 0.1897328296 |
| GSE36640 | Up | 0.1282388419 |
| GSE54402 | Up | 0.1581568235 |
| GSE9593 | Up | 0.2188564247 |
| GSE43922 | Up | 0.0839689419 |
| GSE24585 | Up | 0.3165350000 |
| GSE37065 | Up | 0.2158459210 |
| GSE28863_A1 | Up | 0.2455270268 |
| GSE28863_A2 | Up | 0.4823924282 |
| GSE28863_A3 | Down | -0.3332783698 |
| GSE28863_A4 | Down | -0.3608866009 |
| GSE48662 | Down | -0.0099017116 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-98-5p | MIMAT0000096 | MIRT004947 | qRT-PCR | Functional MTI (Weak) | 17942906 |
| hsa-miR-130b-3p | MIMAT0000691 | MIRT020314 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-186-5p | MIMAT0000456 | MIRT021203 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-186-5p | MIMAT0000456 | MIRT021203 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-93-5p | MIMAT0000093 | MIRT028102 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-26b-5p | MIMAT0000083 | MIRT030177 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-19b-3p | MIMAT0000074 | MIRT031278 | Sequencing | Functional MTI (Weak) | 20371350 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
