HCSGD entry for CNOT3
1. General information
| Official gene symbol | CNOT3 |
|---|---|
| Entrez ID | 4849 |
| Gene full name | CCR4-NOT transcription complex, subunit 3 |
| Other gene symbols | LENG2 NOT3 NOT3H |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000288 | Nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay | TAS | biological_process |
| GO:0000289 | Nuclear-transcribed mRNA poly(A) tail shortening | TAS | biological_process |
| GO:0000932 | Cytoplasmic mRNA processing body | ISS | cellular_component |
| GO:0001829 | Trophectodermal cell differentiation | IEA | biological_process |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005634 | Nucleus | IEA | cellular_component |
| GO:0005737 | Cytoplasm | IDA | cellular_component |
| GO:0005829 | Cytosol | TAS | cellular_component |
| GO:0006351 | Transcription, DNA-templated | IEA | biological_process |
| GO:0006355 | Regulation of transcription, DNA-templated | IEA | biological_process |
| GO:0006417 | Regulation of translation | IEA | biological_process |
| GO:0010467 | Gene expression | TAS | biological_process |
| GO:0016070 | RNA metabolic process | TAS | biological_process |
| GO:0016071 | MRNA metabolic process | TAS | biological_process |
| GO:0030014 | CCR4-NOT complex | IDA | cellular_component |
| GO:0031047 | Gene silencing by RNA | IEA | biological_process |
| GO:2000036 | Regulation of stem cell maintenance | IMP | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.1648392196 | 0.8705790509 | 0.8028743708 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.0251316303 |
| GSE13712_SHEAR | Down | -0.1704638720 |
| GSE13712_STATIC | Up | 0.0366924354 |
| GSE19018 | Up | 0.2125027432 |
| GSE19899_A1 | Up | 0.0056868841 |
| GSE19899_A2 | Up | 0.3594396278 |
| PubMed_21979375_A1 | Down | -0.0806313340 |
| PubMed_21979375_A2 | Up | 1.1026247935 |
| GSE35957 | Down | -0.1689178273 |
| GSE36640 | Up | 0.3074830270 |
| GSE54402 | Up | 0.0111177954 |
| GSE9593 | Down | -0.2064027690 |
| GSE43922 | Up | 0.0501615959 |
| GSE24585 | Down | -0.1723482874 |
| GSE37065 | Down | -0.1802970209 |
| GSE28863_A1 | Up | 0.0330032663 |
| GSE28863_A2 | Up | 0.0938619192 |
| GSE28863_A3 | Up | 0.4357194881 |
| GSE28863_A4 | Up | 0.0782047181 |
| GSE48662 | Up | 0.4000090532 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-185-3p | MIMAT0004611 | MIRT038618 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-652-3p | MIMAT0003322 | MIRT039544 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-let-7c-5p | MIMAT0000064 | MIRT051783 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
