HCSGD entry for NOS1
1. General information
| Official gene symbol | NOS1 |
|---|---|
| Entrez ID | 4842 |
| Gene full name | nitric oxide synthase 1 (neuronal) |
| Other gene symbols | IHPS1 N-NOS NC-NOS NOS bNOS nNOS |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0001666 | Response to hypoxia | IEP | biological_process |
| GO:0001917 | Photoreceptor inner segment | ISS | cellular_component |
| GO:0003958 | NADPH-hemoprotein reductase activity | IBA | molecular_function |
| GO:0004517 | Nitric-oxide synthase activity | IBA ISS | molecular_function |
| GO:0005506 | Iron ion binding | IEA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005516 | Calmodulin binding | IEA | molecular_function |
| GO:0005737 | Cytoplasm | TAS | cellular_component |
| GO:0005829 | Cytosol | TAS | cellular_component |
| GO:0005856 | Cytoskeleton | ISS | cellular_component |
| GO:0006527 | Arginine catabolic process | IC | biological_process |
| GO:0006809 | Nitric oxide biosynthetic process | IBA ISS | biological_process |
| GO:0006941 | Striated muscle contraction | IEA | biological_process |
| GO:0007263 | Nitric oxide mediated signal transduction | IBA | biological_process |
| GO:0007520 | Myoblast fusion | TAS | biological_process |
| GO:0007596 | Blood coagulation | TAS | biological_process |
| GO:0009408 | Response to heat | IDA | biological_process |
| GO:0010181 | FMN binding | ISS | molecular_function |
| GO:0010523 | Negative regulation of calcium ion transport into cytosol | TAS | biological_process |
| GO:0016491 | Oxidoreductase activity | IBA | molecular_function |
| GO:0016529 | Sarcoplasmic reticulum | IDA | cellular_component |
| GO:0017080 | Sodium channel regulator activity | ISS | molecular_function |
| GO:0018119 | Peptidyl-cysteine S-nitrosylation | ISS | biological_process |
| GO:0020037 | Heme binding | ISS | molecular_function |
| GO:0031284 | Positive regulation of guanylate cyclase activity | IBA | biological_process |
| GO:0033555 | Multicellular organismal response to stress | IMP | biological_process |
| GO:0034617 | Tetrahydrobiopterin binding | NAS | molecular_function |
| GO:0034618 | Arginine binding | TAS | molecular_function |
| GO:0035066 | Positive regulation of histone acetylation | IEA | biological_process |
| GO:0042136 | Neurotransmitter biosynthetic process | TAS | biological_process |
| GO:0042383 | Sarcolemma | IDA | cellular_component |
| GO:0042738 | Exogenous drug catabolic process | IEA | biological_process |
| GO:0043197 | Dendritic spine | IEA | cellular_component |
| GO:0043234 | Protein complex | ISS | cellular_component |
| GO:0043267 | Negative regulation of potassium ion transport | IEA | biological_process |
| GO:0044325 | Ion channel binding | ISS | molecular_function |
| GO:0045202 | Synapse | IEA | cellular_component |
| GO:0045776 | Negative regulation of blood pressure | IBA | biological_process |
| GO:0045909 | Positive regulation of vasodilation | IDA IMP | biological_process |
| GO:0045944 | Positive regulation of transcription from RNA polymerase II promoter | IEA | biological_process |
| GO:0046870 | Cadmium ion binding | ISS | molecular_function |
| GO:0048471 | Perinuclear region of cytoplasm | ISS | cellular_component |
| GO:0050660 | Flavin adenine dinucleotide binding | ISS | molecular_function |
| GO:0050661 | NADP binding | ISS | molecular_function |
| GO:0051346 | Negative regulation of hydrolase activity | IEA | biological_process |
| GO:0051612 | Negative regulation of serotonin uptake | IEA | biological_process |
| GO:0051701 | Interaction with host | TAS | biological_process |
| GO:0055117 | Regulation of cardiac muscle contraction | TAS | biological_process |
| GO:0071363 | Cellular response to growth factor stimulus | IEA | biological_process |
| GO:0090382 | Phagosome maturation | TAS | biological_process |
| GO:0097110 | Scaffold protein binding | ISS | molecular_function |
| GO:1902307 | Positive regulation of sodium ion transmembrane transport | ISS | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.9033213480 | 0.6994872839 | 0.9999902473 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.0080595856 |
| GSE13712_SHEAR | Down | -0.0925242328 |
| GSE13712_STATIC | Up | 0.0074581504 |
| GSE19018 | Down | -0.0063883473 |
| GSE19899_A1 | Up | 0.0102412395 |
| GSE19899_A2 | Up | 0.1333558737 |
| PubMed_21979375_A1 | Down | -0.0311874667 |
| PubMed_21979375_A2 | Up | 0.0248857072 |
| GSE35957 | Up | 0.1790983248 |
| GSE36640 | Up | 0.0222710542 |
| GSE54402 | Down | -0.0168357168 |
| GSE9593 | Up | 0.0507149539 |
| GSE43922 | Up | 0.0228808888 |
| GSE24585 | Up | 0.1609912241 |
| GSE37065 | Down | -0.0289428973 |
| GSE28863_A1 | Down | -0.1937485462 |
| GSE28863_A2 | Down | -0.1175164301 |
| GSE28863_A3 | Up | 0.0612454422 |
| GSE28863_A4 | Down | -0.1522902494 |
| GSE48662 | Down | -0.0583725291 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
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- Drugs
Name | Drug | Accession number |
|---|---|---|
| L-N(Omega)-Nitroarginine-2,4-L-Diaminobutyric Amide | DB01821 | EXPT01252 |
| Formic Acid | DB01942 | EXPT01461 |
| 3-Bromo-7-Nitroindazole | DB01997 | EXPT01883 |
| N-{(4s)-4-Amino-5-[(2-Aminoethyl)Amino]Pentyl}-N'-Nitroguanidine | DB02027 | EXPT01253 |
| N-(3-(Aminomethyl)Benzyl)Acetamidine | DB02044 | EXPT00036 |
| L-N(Omega)-Nitroarginine-(4r)-Amino-L-Proline Amide | DB02077 | EXPT01254 |
| N-Isopropyl-N'-Hydroxyguanidine | DB02143 | EXPT01853 |
| N-Omega-Propyl-L-Arginine | DB02644 | EXPT00162 |
| N-Butyl-N'-Hydroxyguanidine | DB02727 | EXPT00698 |
| S-Ethyl-N-[4-(Trifluoromethyl)Phenyl]Isothiourea | DB02991 | EXPT03044 |
| N-Omega-Hydroxy-L-Arginine | DB03144 | EXPT01692 |
| Riboflavin Monophosphate | DB03247 | EXPT01458 |
| N-(4-(2-((3-Chlorophenylmethyl)Amino)Ethyl)Phenyl)-2-Thiophecarboxamidine | DB03449 | EXPT00560 |
| 2'-Monophosphoadenosine 5'-Diphosphoribose | DB03461 | EXPT02293 |
| S-Ethyl-N-Phenyl-Isothiourea | DB03707 | EXPT02689 |
| N5-(1-Imino-3-Butenyl)-L-Ornithine | DB03710 | EXPT03224 |
| 5-N-Allyl-Arginine | DB03892 | EXPT00563 |
| NXN-188 | DB06096 | - |
| N-{(3S,4S)-4-[(6-AMINO-4-METHYLPYRIDIN-2-YL)METHYL]PYRROLIDIN-3-YL}-N'-(4-CHLOROBENZYL)ETHANE-1,2-DIAMINE | DB08018 | - |
| N-{(3R,4S)-4-[(6-amino-4-methylpyridin-2-yl)methyl]pyrrolidin-3-yl}-N'-(3-chlorobenzyl)ethane-1,2-diamine | DB08019 | - |
- MicroRNAs
- mirTarBase
No target information from mirTarBase
- mirTarBase
- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 2 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 26408226 | Protective effects of NMDA receptor antagonist, memantine, against senescence of PC12 cells: A possible role of nNOS and combined effects with donepezil |
| 26408226 | Therefore, we investigated whether glutamate activates nNOS and memantine reverses it |
| 26408226 | Treatment with glutamate increased nNOS expression, activity, and production of NO,whereas memantine blocked them |
| 25360110 | Thus, in the adult and aged distal parts of the colon a marked decrease in relative gene expression of neural key genes like NGFR, RET, NOS1 and a concurrent increase of CHAT were observed |
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