HCSGD entry for NODAL

1. General information

Official gene symbolNODAL
Entrez ID4838
Gene full namenodal growth differentiation factor
Other gene symbolsHTX5
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

color bar
This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000122Negative regulation of transcription from RNA polymerase II promoterIEAbiological_process
GO:0001831Trophectodermal cellular morphogenesisIEAbiological_process
GO:0001842Neural fold formationIEAbiological_process
GO:0001889Liver developmentIEAbiological_process
GO:0001890Placenta developmentIMPbiological_process
GO:0001892Embryonic placenta developmentIEAbiological_process
GO:0001893Maternal placenta developmentIEAbiological_process
GO:0001944Vasculature developmentIEAbiological_process
GO:0001947Heart loopingIEAbiological_process
GO:0002085Inhibition of neuroepithelial cell differentiationIEAbiological_process
GO:0005125Cytokine activityIEAmolecular_function
GO:0005576Extracellular regionIEAcellular_component
GO:0005615Extracellular spaceIDAcellular_component
GO:0007420Brain developmentIEAbiological_process
GO:0008083Growth factor activityIEAmolecular_function
GO:0009880Embryonic pattern specificationIEAbiological_process
GO:0010085Polarity specification of proximal/distal axisIEAbiological_process
GO:0010470Regulation of gastrulationIEAbiological_process
GO:0010575Positive regulation vascular endothelial growth factor productionIMPbiological_process
GO:0010862Positive regulation of pathway-restricted SMAD protein phosphorylationIMPbiological_process
GO:0016015Morphogen activityNASmolecular_function
GO:0019827Stem cell maintenanceIEAbiological_process
GO:0022409Positive regulation of cell-cell adhesionIMPbiological_process
GO:0032927Positive regulation of activin receptor signaling pathwayIGIbiological_process
GO:0033505Floor plate morphogenesisIEAbiological_process
GO:0035987Endodermal cell differentiationIMPbiological_process
GO:0040007GrowthIEAbiological_process
GO:0042074Cell migration involved in gastrulationIEAbiological_process
GO:0043280Positive regulation of cysteine-type endopeptidase activity involved in apoptotic processIDAbiological_process
GO:0045766Positive regulation of angiogenesisIMPbiological_process
GO:0045944Positive regulation of transcription from RNA polymerase II promoterIEAbiological_process
GO:0048018Receptor agonist activityIEAmolecular_function
GO:0048327Axial mesodermal cell fate specificationIEAbiological_process
GO:0048382Mesendoderm developmentIMPbiological_process
GO:0048546Digestive tract morphogenesisIEAbiological_process
GO:0048701Embryonic cranial skeleton morphogenesisIEAbiological_process
GO:0048859Formation of anatomical boundaryIEAbiological_process
GO:0050679Positive regulation of epithelial cell proliferationIDAbiological_process
GO:0051091Positive regulation of sequence-specific DNA binding transcription factor activityIMPbiological_process
GO:0060136Embryonic process involved in female pregnancyIEAbiological_process
GO:0060137Maternal process involved in parturitionIEAbiological_process
GO:0060391Positive regulation of SMAD protein import into nucleusIMPbiological_process
GO:0060395SMAD protein signal transductionIEAbiological_process
GO:0060460Left lung morphogenesisIEAbiological_process
GO:0060766Negative regulation of androgen receptor signaling pathwayIDAbiological_process
GO:0060802Epiblast cell-extraembryonic ectoderm cell signaling involved in anterior/posterior axis specificationIEAbiological_process
GO:0070374Positive regulation of ERK1 and ERK2 cascadeIMPbiological_process
GO:0070698Type I activin receptor bindingIMPmolecular_function
GO:0090010Transforming growth factor beta receptor signaling pathway involved in primitive streak formationIEAbiological_process
GO:1900164Nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetryIEAbiological_process
GO:1900224Positive regulation of nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetryISSbiological_process
GO:1901164Negative regulation of trophoblast cell migrationIDAbiological_process
GO:1901383Negative regulation of chorionic trophoblast cell proliferationIDAbiological_process
GO:2000036Regulation of stem cell maintenanceTASbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.54550297480.92982672770.99999024731.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.0417256560
GSE13712_SHEARDown-0.0097692522
GSE13712_STATICDown-0.1300062198
GSE19018Up0.0465745505
GSE19899_A1Up0.0766647920
GSE19899_A2Up0.1258285929
PubMed_21979375_A1Up0.1092292277
PubMed_21979375_A2Down-0.0700787429
GSE35957Up0.2455382965
GSE36640Up0.0903761239
GSE54402Up0.0839250383
GSE9593Up0.0501678472
GSE43922Up0.0171527094
GSE24585Up0.1932660786
GSE37065Up0.0304232581
GSE28863_A1Down-0.0147180185
GSE28863_A2Up0.0226317477
GSE28863_A3Up0.2178544171
GSE28863_A4Up0.0424858486
GSE48662Down-0.0551043517

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-122-5pMIMAT0000421MIRT023342MicroarrayFunctional MTI (Weak)17612493
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    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.