HCSGD entry for NME4
1. General information
| Official gene symbol | NME4 |
|---|---|
| Entrez ID | 4833 |
| Gene full name | NME/NM23 nucleoside diphosphate kinase 4 |
| Other gene symbols | NDPK-D NM23H4 nm23-H4 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0004550 | Nucleoside diphosphate kinase activity | EXP IEA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005524 | ATP binding | IEA | molecular_function |
| GO:0005739 | Mitochondrion | IEA TAS | cellular_component |
| GO:0005743 | Mitochondrial inner membrane | TAS | cellular_component |
| GO:0005758 | Mitochondrial intermembrane space | IEA | cellular_component |
| GO:0006183 | GTP biosynthetic process | IEA | biological_process |
| GO:0006228 | UTP biosynthetic process | IEA | biological_process |
| GO:0006241 | CTP biosynthetic process | IEA | biological_process |
| GO:0009116 | Nucleoside metabolic process | TAS | biological_process |
| GO:0015949 | Nucleobase-containing small molecule interconversion | TAS | biological_process |
| GO:0032403 | Protein complex binding | IEA | molecular_function |
| GO:0044281 | Small molecule metabolic process | TAS | biological_process |
| GO:0046872 | Metal ion binding | IEA | molecular_function |
| GO:0055086 | Nucleobase-containing small molecule metabolic process | TAS | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.4488697010 | 0.0936662399 | 0.9999902473 | 0.5831100047 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.3111432673 |
| GSE13712_SHEAR | Down | -0.2874071406 |
| GSE13712_STATIC | Down | -0.0087208367 |
| GSE19018 | Up | 0.4562764824 |
| GSE19899_A1 | Down | -0.1595353124 |
| GSE19899_A2 | Up | 0.6248753583 |
| PubMed_21979375_A1 | Down | -0.5838028416 |
| PubMed_21979375_A2 | Up | 0.2476559300 |
| GSE35957 | Down | -0.6118991462 |
| GSE36640 | Up | 0.5632869322 |
| GSE54402 | Down | -0.0110541677 |
| GSE9593 | Up | 0.2916805778 |
| GSE43922 | Down | -0.0360302268 |
| GSE24585 | Up | 0.1051619894 |
| GSE37065 | Down | -0.3734508972 |
| GSE28863_A1 | Down | -0.4934186955 |
| GSE28863_A2 | Down | -0.3806013515 |
| GSE28863_A3 | Down | -0.0563224405 |
| GSE28863_A4 | Down | -0.0152600952 |
| GSE48662 | Up | 0.1711106963 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-124-3p | MIMAT0000422 | MIRT002663 | Microarray | Functional MTI (Weak) | 15685193 |
| hsa-miR-769-3p | MIMAT0003887 | MIRT039059 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-193b-3p | MIMAT0002819 | MIRT041585 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-484 | MIMAT0002174 | MIRT042220 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-378a-3p | MIMAT0000732 | MIRT043937 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-let-7e-5p | MIMAT0000066 | MIRT051476 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-let-7c-5p | MIMAT0000064 | MIRT051761 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-let-7b-5p | MIMAT0000063 | MIRT052182 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-let-7a-5p | MIMAT0000062 | MIRT052558 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
