HCSGD entry for NKX2-2

1. General information

Official gene symbolNKX2-2
Entrez ID4821
Gene full nameNK2 homeobox 2
Other gene symbolsNKX2.2 NKX2B
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0001159Core promoter proximal region DNA bindingISSmolecular_function
GO:0003323Type B pancreatic cell developmentIEAbiological_process
GO:0003326Pancreatic A cell fate commitmentIEAbiological_process
GO:0003327Type B pancreatic cell fate commitmentIEAbiological_process
GO:0003329Pancreatic PP cell fate commitmentIEAbiological_process
GO:0003682Chromatin bindingISSmolecular_function
GO:0003700Sequence-specific DNA binding transcription factor activityIEAmolecular_function
GO:0003713Transcription coactivator activityISSmolecular_function
GO:0005654NucleoplasmTAScellular_component
GO:0006351Transcription, DNA-templatedIEAbiological_process
GO:0007224Smoothened signaling pathwayIEAbiological_process
GO:0007420Brain developmentTASbiological_process
GO:0008134Transcription factor bindingIEAmolecular_function
GO:0009749Response to glucoseIEAbiological_process
GO:0014003Oligodendrocyte developmentIEAbiological_process
GO:0021522Spinal cord motor neuron differentiationIEAbiological_process
GO:0021530Spinal cord oligodendrocyte cell fate specificationIEAbiological_process
GO:0021554Optic nerve developmentIEAbiological_process
GO:0031018Endocrine pancreas developmentTASbiological_process
GO:0032570Response to progesteroneIEAbiological_process
GO:0043565Sequence-specific DNA bindingIEAmolecular_function
GO:0045665Negative regulation of neuron differentiationIEAbiological_process
GO:0045666Positive regulation of neuron differentiationIEAbiological_process
GO:0045944Positive regulation of transcription from RNA polymerase II promoterIEAbiological_process
GO:0048565Digestive tract developmentIEAbiological_process
GO:0048665Neuron fate specificationIEAbiological_process
GO:0048708Astrocyte differentiationIEAbiological_process
GO:0048714Positive regulation of oligodendrocyte differentiationIEAbiological_process
GO:0051091Positive regulation of sequence-specific DNA binding transcription factor activityISSbiological_process
GO:0060580Ventral spinal cord interneuron fate determinationIEAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.19235731550.93012517760.85064464051.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.1159746933
GSE13712_SHEARUp0.0005015235
GSE13712_STATICDown-0.1390841038
GSE19018Up0.0989926663
GSE19899_A1Up0.1765376590
GSE19899_A2Down-0.1050449050
PubMed_21979375_A1Up0.3907795120
PubMed_21979375_A2Up0.2989675763
GSE35957Up0.0489360741
GSE36640Up0.0599759955
GSE54402Up0.2082164425
GSE9593Up0.0882608165
GSE43922Down-0.0065078816
GSE24585Up0.3635989643
GSE37065Down-0.0087117372
GSE28863_A1Down-0.0792132244
GSE28863_A2Down-0.0535072302
GSE28863_A3Up0.3242642189
GSE28863_A4Up0.2975915863
GSE48662Up0.0592678007

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-9-5pMIMAT0000441MIRT021435MicroarrayFunctional MTI (Weak)17612493
hsa-miR-26b-5pMIMAT0000083MIRT029734MicroarrayFunctional MTI (Weak)19088304
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    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.