HCSGD entry for NGF

1. General information

Official gene symbolNGF
Entrez ID4803
Gene full namenerve growth factor (beta polypeptide)
Other gene symbolsBeta-NGF HSAN5 NGFB
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

color bar
This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000186Activation of MAPKK activityTASbiological_process
GO:0005057Receptor signaling protein activityIEAmolecular_function
GO:0005163Nerve growth factor receptor bindingIPImolecular_function
GO:0005576Extracellular regionTAScellular_component
GO:0005615Extracellular spaceIEAcellular_component
GO:0005768EndosomeTAScellular_component
GO:0005796Golgi lumenTAScellular_component
GO:0006954Inflammatory responseIEAbiological_process
GO:0007169Transmembrane receptor protein tyrosine kinase signaling pathwayTASbiological_process
GO:0007202Activation of phospholipase C activityTASbiological_process
GO:0007264Small GTPase mediated signal transductionTASbiological_process
GO:0007265Ras protein signal transductionTASbiological_process
GO:0007422Peripheral nervous system developmentIEAbiological_process
GO:0007613MemoryIEAbiological_process
GO:0008083Growth factor activityIEAmolecular_function
GO:0008344Adult locomotory behaviorIEAbiological_process
GO:0008625Extrinsic apoptotic signaling pathway via death domain receptorsIDAbiological_process
GO:0009314Response to radiationIEAbiological_process
GO:0009612Response to mechanical stimulusIEAbiological_process
GO:0010193Response to ozoneIEAbiological_process
GO:0010628Positive regulation of gene expressionIMPbiological_process
GO:0019233Sensory perception of painIEAbiological_process
GO:0031954Positive regulation of protein autophosphorylationIEAbiological_process
GO:0032455Nerve growth factor processingTASbiological_process
GO:0032496Response to lipopolysaccharideIEAbiological_process
GO:0035094Response to nicotineIEAbiological_process
GO:0042493Response to drugIEAbiological_process
GO:0043065Positive regulation of apoptotic processTASbiological_process
GO:0043066Negative regulation of apoptotic processTASbiological_process
GO:0043281Regulation of cysteine-type endopeptidase activity involved in apoptotic processTASbiological_process
GO:0043434Response to peptide hormoneIEAbiological_process
GO:0043524Negative regulation of neuron apoptotic processIEAbiological_process
GO:0045666Positive regulation of neuron differentiationIEAbiological_process
GO:0045773Positive regulation of axon extensionIEAbiological_process
GO:0045786Negative regulation of cell cycleTASbiological_process
GO:0046928Regulation of neurotransmitter secretionIEAbiological_process
GO:0048011Neurotrophin TRK receptor signaling pathwayTASbiological_process
GO:0048015Phosphatidylinositol-mediated signalingTASbiological_process
GO:0048812Neuron projection morphogenesisIDAbiological_process
GO:0050770Regulation of axonogenesisTASbiological_process
GO:0050772Positive regulation of axonogenesisTASbiological_process
GO:0051091Positive regulation of sequence-specific DNA binding transcription factor activityIEAbiological_process
GO:0051384Response to glucocorticoidIEAbiological_process
GO:0051388Positive regulation of neurotrophin TRK receptor signaling pathwayIEAbiological_process
GO:0051402Neuron apoptotic processIEAbiological_process
GO:0051602Response to electrical stimulusIEAbiological_process
GO:0097190Apoptotic signaling pathwayTASbiological_process
GO:0097192Extrinsic apoptotic signaling pathway in absence of ligandIEAbiological_process
GO:2000648Positive regulation of stem cell proliferationIEAbiological_process
GO:2000675Negative regulation of type B pancreatic cell apoptotic processIEAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.95019632990.01435290830.99999024730.2356724267

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.2945638440
GSE13712_SHEARDown-0.0077821341
GSE13712_STATICDown-0.0464707742
GSE19018Down-1.1049938759
GSE19899_A1Down-0.2154085787
GSE19899_A2Down-0.6419031418
PubMed_21979375_A1Down-0.6942289766
PubMed_21979375_A2Down-1.2065850822
GSE35957Down-0.0056040379
GSE36640Down-1.1355020449
GSE54402Down-0.2159660330
GSE9593Down-0.0129182305
GSE43922Up0.0510789002
GSE24585Up0.0064773638
GSE37065Up0.1170384137
GSE28863_A1Down-0.4121299937
GSE28863_A2Down-0.2260533125
GSE28863_A3Down-0.1872168919
GSE28863_A4Up0.2479432763
GSE48662Up0.4104367347

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

RI 624DB05892 -

  • MicroRNAs

    • mirTarBase
No target information from mirTarBase
    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 3 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

24198727In addition, both treatments induced the expression of a variety of cytokines, including interleukin-1beta (IL-1beta) and nerve growth factor (NGF)
24198727AdRas12V infection induced IL-1beta expression more significantly than H(2)O(2) treatment, whereas both treatments induced comparable mRNA and protein expression levels of NGF
17635673The neurotrophin receptor tropomyosin-related kinase A (TrkA) and its ligand nerve growth factor (NGF) are expressed in astrocytomas, and an inverse association of TrkA expression with malignancy grade was described
17635673We obtained three stable clones, all of which responded with striking cytoplasmic vacuolation and subsequent cell death to NGF
12803109What is important, however, is the induction of cells that have an atypical to this pathway allure staining positive for the neurofilament 3A10 monoclonal antibody, specific for nerve cells and the anti-p75 (Nerve Growth Factor Receptor) monoclonal antibody
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