HCSGD entry for NFYB
1. General information
| Official gene symbol | NFYB |
|---|---|
| Entrez ID | 4801 |
| Gene full name | nuclear transcription factor Y, beta |
| Other gene symbols | CBF-A CBF-B HAP3 NF-YB |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0003677 | DNA binding | IDA | molecular_function |
| GO:0003700 | Sequence-specific DNA binding transcription factor activity | IEA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005634 | Nucleus | IDA IEA | cellular_component |
| GO:0005654 | Nucleoplasm | TAS | cellular_component |
| GO:0006351 | Transcription, DNA-templated | IEA | biological_process |
| GO:0006355 | Regulation of transcription, DNA-templated | IDA IEA | biological_process |
| GO:0016602 | CCAAT-binding factor complex | IDA | cellular_component |
| GO:0043565 | Sequence-specific DNA binding | IEA | molecular_function |
| GO:0044255 | Cellular lipid metabolic process | TAS | biological_process |
| GO:0044281 | Small molecule metabolic process | TAS | biological_process |
| GO:0045893 | Positive regulation of transcription, DNA-templated | IEA | biological_process |
| GO:0046982 | Protein heterodimerization activity | IEA | molecular_function |
| GO:0070491 | Repressing transcription factor binding | IPI | molecular_function |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.9964435204 | 0.0008699783 | 0.9999902473 | 0.0564007389 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.8233849930 |
| GSE13712_SHEAR | Down | -0.6325260770 |
| GSE13712_STATIC | Down | -0.2606352247 |
| GSE19018 | Down | -0.4929749256 |
| GSE19899_A1 | Down | -0.8399454878 |
| GSE19899_A2 | Down | -1.6395771445 |
| PubMed_21979375_A1 | Down | -1.0528481789 |
| PubMed_21979375_A2 | Down | -2.1367642381 |
| GSE35957 | Up | 0.0327962693 |
| GSE36640 | Down | -1.1068873739 |
| GSE54402 | Down | -0.9973588121 |
| GSE9593 | Down | -0.4507394931 |
| GSE43922 | Down | -1.2289207568 |
| GSE24585 | Down | -0.0675184299 |
| GSE37065 | Down | -0.0488522306 |
| GSE28863_A1 | Up | 0.2507290056 |
| GSE28863_A2 | Down | -0.3933716795 |
| GSE28863_A3 | Down | -0.0625715483 |
| GSE28863_A4 | Down | -0.0694367197 |
| GSE48662 | Down | -0.0477536527 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-485-3p | MIMAT0002176 | MIRT005607 | Luciferase reporter assay//qRT-PCR//Western blot | Functional MTI | 21252292 |
| hsa-miR-181a-5p | MIMAT0000256 | MIRT025209 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-30c-5p | MIMAT0000244 | MIRT047937 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 8864061 | Both NF-YA and NF-YB were constitutively expressed at mRNA level in IMR-90 cells |
| 8864061 | However, expression of NF-YA, and to a lesser degree, NF-YB, at the protein level were clearly age-dependent |
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